ReviewAsian journal of andrology
Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer.
Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor.BioMed research international · 2016Trial
- Sociodemographic Trends and Perinatal Outcomes in Fathers 50 Years and Older.JAMA network open · 2024Article
- The Role of Advanced Parental Age in Reproductive Genetics.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- De Novo Heterozygous Mutation in FGFR2 Causing Type II Pfeiffer Syndrome.Case reports in genetics · 2022Article
- Diagnostic Yield and Economic Implications of Whole-Exome Sequencing for ASD Diagnosis in Israel.Genes · 2021Article
- Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring.Biomedical reports · 2020Article
- Article
- Family-based germline sequencing in children with cancer.Oncogene · 2019Review
- Peroxiredoxin 6: The Protector of Male Fertility.Antioxidants (Basel, Switzerland) · 2018Review
- Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study.BMJ (Clinical research ed.) · 2018Article
- Oxidative Stress and Polymorphism inJournal of pediatric genetics · 2018Article
- Male Fertility Preservation.Current urology reports · 2018Review
- The role of advanced paternal age in modern reproductive medicine.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As couples are increasingly delaying parenthood, the effect of the aging men and women on reproductive outcomes has been an area of increased interest. Advanced paternal age has been shown to independently affect the entire spectrum of male fertility as assessed by reductions in sperm quality and fertilization (both assisted and unassisted). Moreover, epidemiological data suggest that paternal age can lead to higher rates of adverse birth outcomes and congenital anomalies. Mounting evidence also suggests increased risk of specific pediatric and adult disease states ranging from cancer to behavioral traits. While disease states associated with advancing paternal age have been well described, consensus recommendations for neonatal screening have not been as widely implemented as have been with advanced maternal age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.