ArticleAsian journal of andrology
Human semen quality and the secondary sex ratio.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Does a Father's Social Environment Influence Their Sons' Sperm Sex Ratio? Potential for the Epigenetic Transmission of a Sex-Allocating Mechanism.Ecology and evolution · 2025Article
- Surface-Enhanced Raman Spectroscopy on Gold Nanoparticle for Sperm Quality Discrimination.Molecules (Basel, Switzerland) · 2025Article
- The Impact of Lifestyle on the Secondary Sex Ratio: A Review.Life (Basel, Switzerland) · 2024Review
- Multiparametric Study of Antioxidant Effect on Ram Sperm Cryopreservation-From Field Trials to Research Bench.Animals : an open access journal from MDPI · 2021Article
- Comparing the Effect of Different Antibiotics in Frozen-Thawed Ram Sperm: Is It Possible to Avoid Their Addition?Frontiers in veterinary science · 2021Article
- Effects of Socio-demographic Factors on the Decreasing Trend in the Sex Ratio at Birth in Korea, 1997-2017.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2020Article
- Stereotypic behaviour predicts reproductive performance and litter sex ratio in giant pandas.Scientific reports · 2020Article
- The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study.Reproductive biology and endocrinology : RB&E · 2019Article
- Secondary sex ratio in assisted reproduction: an analysis of 1 376 454 treatment cycles performed in the UK.Human reproduction open · 2019Article
- Maternal and paternal serum concentrations of persistent organic pollutants and the secondary sex ratio: A population-based preconception cohort study.Environmental research · 2018Article
- Revisiting the Trivers-Willard theory on birth sex ratio bias: Role of paternal condition in a Malagasy primate.PloS one · 2018Article
- What Does a Single Semen Sample Tell You? Implications for Male Factor Infertility Research.American journal of epidemiology · 2017Article
- Preconception stress and the secondary sex ratio in a population-based preconception cohort.Fertility and sterility · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the association between semen quality and the secondary sex ratio (SSR), defined as the ratio of male to female live births. Our study cohort comprised 227 male partners who were enrolled prior to conception in Michigan and Texas between 2005 and 2009, and prospectively followed through delivery of a singleton birth. The male partners provided a baseline and a follow-up semen sample a month apart. Semen analysis was conducted to assess 27 parameters including five general characteristics, six sperm head measures, 14 morphology measures, and two sperm chromatin stability assay measures. Modified Poisson regression models with a robust error variance were used to estimate the relative risk (RR) and 95% confidence interval (95% CI) of a male birth for each semen parameter, after adjusting for potential confounders. Of the 27 semen parameters, only the percentage of bicephalic sperm was significantly associated with the SSR (2 nd vs 1 st quartile, RR, 0.65, 95% CI, 0.45-0.95, P = 0.03; 4 th vs 1 st quartile, RR, 0.61, 95% CI, 0.38-1.00, P < 0.05 before rounding to two decimal places), suggestive of a higher percentage of bicephalic sperm being associated with an excess of female births. Given the exploratory design of the present study, this preconception cohort study suggests no clear signal that human semen quality is associated with offspring sex determination.
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Registered trials
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