ArticleScientific reports2016
Insights into Adaptations to a Near-Obligate Nematode Endoparasitic Lifestyle from the Finished Genome of Drechmeria coniospora.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
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- Telomere-to-Telomere Genome Assembly of Tibetan Medicinal MushroomJournal of fungi (Basel, Switzerland) · 2023Article
- Nonbacterial Microflora in Wastewater Treatment Plants: an Underappreciated Potential Source of Pathogens.Microbiology spectrum · 2023Article
- Species-specific effects of the introduction of Aspergillus nidulans gfdB in osmophilic aspergilli.Applied microbiology and biotechnology · 2023Article
- The transcriptome of the entomopathogenic fungusPeerJ · 2023Article
- Phylogeny and Systematics of the GenusJournal of fungi (Basel, Switzerland) · 2022Article
- Pathogenicity and Metabolites of Endoparasitic Nematophagous FungusMicroorganisms · 2021Article
- Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences.PLoS genetics · 2021Article
- Increased Pathogenicity of the Nematophagous FungusFrontiers in fungal biology · 2021Article
- Fungi-Nematode Interactions: Diversity, Ecology, and Biocontrol Prospects in Agriculture.Journal of fungi (Basel, Switzerland) · 2020Review
- Secondary metabolites from hypocrealean entomopathogenic fungi: novel bioactive compounds.Natural product reports · 2020Review
- Long-read only assembly of Drechmeria coniospora genomes reveals widespread chromosome plasticity and illustrates the limitations of current nanopore methods.GigaScience · 2020Article
- The Third International Symposium on Fungal Stress - ISFUS.Fungal biology · 2020Article
- Genome-Wide Analyses of Repeat-Induced Point Mutations in the Ascomycota.Frontiers in microbiology · 2020Article
- Intercellular communication is required for trap formation in the nematode-trapping fungus Duddingtonia flagrans.PLoS genetics · 2019Article
- Duplications and losses of genes encoding known elements of the stress defence system of the Aspergilli contribute to the evolution of these filamentous fungi but do not directly influence their environmental stress tolerance.Studies in mycology · 2018Article
- Genome and secretome analysis of Pochonia chlamydosporia provide new insight into egg-parasitic mechanisms.Scientific reports · 2018Article
- Comparative genomic analyses reveal the features for adaptation to nematodes in fungi.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
Corrections and comments
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Authors and funding
22 authors at 11 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nematophagous fungi employ three distinct predatory strategies: nematode trapping, parasitism of females and eggs, and endoparasitism. While endoparasites play key roles in controlling nematode populations in nature, their application for integrated pest management is hindered by the limited understanding of their biology. We present a comparative analysis of a high quality finished genome assembly of Drechmeria coniospora, a model endoparasitic nematophagous fungus, integrated with a transcriptomic study. Adaptation of D. coniospora to its almost completely obligate endoparasitic lifestyle led to the simplification of many orthologous gene families involved in the saprophytic trophic mode, while maintaining orthologs of most known fungal pathogen-host interaction proteins, stress response circuits and putative effectors of the small secreted protein type. The need to adhere to and penetrate the host cuticle led to a selective radiation of surface proteins and hydrolytic enzymes. Although the endoparasite has a simplified secondary metabolome, it produces a novel peptaibiotic family that shows antibacterial, antifungal and nematicidal activities. Our analyses emphasize the basic malleability of the D. coniospora genome: loss of genes advantageous for the saprophytic lifestyle; modulation of elements that its cohort species utilize for entomopathogenesis; and expansion of protein families necessary for the nematode endoparasitic lifestyle.
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