ArticleWiener klinische Wochenschrift2016
Crizotinib-induced toxicity in an experimental rat model.
Article in Wiener klinische Wochenschrift, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- An Insight on the Pathways Involved in Crizotinib and Sunitinib Induced Hepatotoxicity in HepG2 Cells and Animal Model.Frontiers in oncology · 2022Article
- Renal Injury during Long-Term Crizotinib Therapy.International journal of molecular sciences · 2018Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
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Abstract
aimThe aim of the present study was to evaluate the effect of crizotinib on visceral organs in an experimental rat model.
methodsEighteen Wistar albino rats were divided into three groups: experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively.
resultsSubjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas.
conclusionThis study is the first to evaluate the histopathological features of toxicity of crizotinib in a rat model.
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