Evidence map›Paper›PMID 26975400›Full record

ArticleInternational ophthalmology2017

Evaluating the presence of Toxoplasma gondii in peripheral blood of patients with diverse forms of uveitis.

Rubens N Belfort, Jordan Isenberg, Bruno F Fernandes, Sebastian Di Cesare, Rubens Belfort, Miguel N Burnier

Abstract read
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In one paragraph

Article in International ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rubens N BelfortThe Henry C. Witleson Ocular Pathology Laboratory, McGill University, 3375 University, Room 216, Montréal, QC, Canada.
Jordan IsenbergThe Henry C. Witleson Ocular Pathology Laboratory, McGill University, 3375 University, Room 216, Montréal, QC, Canada. chaughten@gmail.com.
Bruno F FernandesThe Henry C. Witleson Ocular Pathology Laboratory, McGill University, 3375 University, Room 216, Montréal, QC, Canada.
Sebastian Di CesareThe Henry C. Witleson Ocular Pathology Laboratory, McGill University, 3375 University, Room 216, Montréal, QC, Canada.
Rubens BelfortDepartment of Ophthalmology and Visual Sciences, Vision Institute, Federal University of São Paulo, Rua Botucatu, 821, São Paulo, SP, Brazil.
Miguel N BurnierThe Henry C. Witleson Ocular Pathology Laboratory, McGill University, 3375 University, Room 216, Montréal, QC, Canada.
McGill University · CAInstituto da Visão · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to evaluate the presence of Toxoplasmosis gondii in samples of peripheral blood from patients with varying etiologies of uveitis. Whole blood from patients with different forms of uveitis was tested for the presence of T. gondii using real-time PCR targeting the well-characterized 529 bp fragment. Extracted DNA was both frozen. Thirty-one patients were included in the current study and grouped as follows: acute toxoplasmosis (n = 10); toxoplasmic retinal scars (n = 9); non-infectious etiologies of uveitis (n = 6); and IgG negative for toxoplasmosis (n = 6). In total, only two patients were shown to have circulating T. gondii in peripheral blood; both of these patients were IgG positive for toxoplasmosis, were receiving immunosuppressive therapy for autoimmune uveitis, and had no clinical features of toxoplasmosis. T. gondii was identified in peripheral blood of some immunosuppressed patients. No other patients, including those with acute toxoplasmosis, had circulating parasites in peripheral blood.

Indexed as

AdultAntibodies, ProtozoanDNA, ProtozoanFemaleHumansImmunoglobulin GMalePolymerase Chain ReactionSerologic TestsToxoplasmaToxoplasmosis, OcularUveitisYoung AdultAntibodies, ProtozoanDNA, ProtozoanImmunoglobulin GPCRToxoplasma gondiiUveitis

Identifiers

PMID26975400
OpenAlexW2298450464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.