ArticlePediatric nephrology (Berlin, Germany)2016
Fluid overload and outcomes in neonates receiving continuous renal replacement therapy.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Association between fluid overload and mortality in newborns: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Korean Society of Nephrology 2025 Evidence-Based Clinical Practice Guideline for Continuous Kidney Replacement Therapy.Electrolyte & blood pressure : E & BP · 2026Review
- Korean Society of Nephrology 2025 evidence-based clinical practice guideline for continuous kidney replacement therapy.Kidney research and clinical practice · 2026Article
- Early continuous renal replacement therapy for acute kidney injury in a very low birth weight infant: a case report and literature review.Frontiers in medicine · 2026Article
- Continuous renal replacement therapy in neonates with multiple organ dysfunction syndrome: clinical utilization effects and outcomes.Italian journal of pediatrics · 2025Article
- Continuous Renal Replacement Therapy in Critically-Ill Term and Preterm Newborns: A Single-Center Study in Belgrade.Children (Basel, Switzerland) · 2025Article
- Characteristics and outcomes of children ≤ 10 kg receiving continuous kidney replacement therapy: a WE-ROCK study.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Effectiveness and feasibility of continuous renal replacement therapy for acute kidney injury in neonates weighing 3 kg or less: a two-centre, retrospective study.BMJ paediatrics open · 2024Article
- Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- New perspectives in pediatric dialysis technologies: the case for neonates and infants with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024Article
- Kidney support for babies: building a comprehensive and integrated neonatal kidney support therapy program.Pediatric nephrology (Berlin, Germany) · 2023Review
- Regional citrate anticoagulation for continuous renal replacement therapy in newborns.Frontiers in pediatrics · 2023Article
- Neonatal fluid overload-ignorance is no longer bliss.Pediatric nephrology (Berlin, Germany) · 2023Review
- Optimal stage of initiating continuous renal replacement therapy in the treatment of neonatal acute kidney injury.Experimental and therapeutic medicine · 2022Article
- Effect of fluid load on the prognosis of children with sepsis-associated acute kidney injury undergoing continuous renal replacement therapy.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Article
- Management of Acute Kidney Injury in Extremely Low Birth Weight Infants.Frontiers in pediatrics · 2022Review
- I-KID study protocol: evaluation of efficacy, outcomes and safety of a new infant haemodialysis and ultrafiltration machine in clinical use: a randomised clinical investigation using a cluster stepped-wedge design.BMJ paediatrics open · 2021Article
- Fluid Balance in the Critically Ill Child Section: "How Bad Is Fluid in Neonates?"Frontiers in pediatrics · 2021Review
- Challenges of acute peritoneal dialysis in extremely-low-birth-weight infants: a retrospective cohort study.BMC nephrology · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContinuous renal replacement therapy (CRRT) has emerged as the modality of choice for the management of high-risk neonates with acute kidney injury (AKI), inborn errors of metabolism and multi-organ dysfunction. The aim of this study was to evaluate fluid overload (FO) and investigate the factors associated with outcomes in neonates undergoing CRRT.
methodsWe retrospectively reviewed the medical records of 34 neonates with AKI who were admitted to the neonatal intensive care unit (NICU) of Samsung Medical Center, Seoul, Republic of Korea between January 2007 and December 2014 where they underwent at least 24 h of CRRT.
resultsThe survival rates of patients with an FO of ≥30 % at the time of CRRT initiation were lower than those of patients with an FO of <30 % at the same time-point. Univariate Cox regression analysis revealed that a higher percentage FO at CRRT initiation and decreased urine output at the end of CRRT were associated with mortality, and multivariate Cox regression analysis indicated that mortality was associated with decreased urine output at the end of CRRT. Univariate linear regression analysis revealed that the length of hospital stay was associated with higher levels of serum creatinine at CRRT initiation, longer stay in the NICU prior to initiation of CRRT, longer duration of CRRT and lower body weight at the time of NICU admission.
conclusionsNeonates with a higher percentage FO and higher levels of serum creatinine at CRRT initiation showed poor outcomes. Early initiation of CRRT before the development of severe FO or azotemia might improve the outcomes of neonates requiring CRRT.
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