ArticleJournal of the American Society for Mass Spectrometry2016
Making Mass Spectrometry See the Light: The Promises and Challenges of Cryogenic Infrared Ion Spectroscopy as a Bioanalytical Technique.
Article in Journal of the American Society for Mass Spectrometry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Isomeric Speciation of Bisbenzoxazine Intermediates by Ion Spectroscopy and Ion Mobility Mass Spectrometry.ACS omega · 2024Article
- Structural Elucidation of Agrochemical Metabolic Transformation Products Based on Infrared Ion Spectroscopy to Improve In Silico Toxicity Assessment.Chemical research in toxicology · 2024Article
- Structural Elucidation of Agrochemicals and Related Derivatives Using Infrared Ion Spectroscopy.Environmental science & technology · 2022Article
- Metabolite Identification Using Infrared Ion Spectroscopy─Novel Biomarkers for Pyridoxine-Dependent Epilepsy.Analytical chemistry · 2021Article
- Evaluation of table-top lasers for routine infrared ion spectroscopy in the analytical laboratory.The Analyst · 2021Article
- Quantum Chemistry Calculations for Metabolomics.Chemical reviews · 2021Review
- Ultraviolet Photodissociation Mass Spectrometry for Analysis of Biological Molecules.Chemical reviews · 2020Review
- Ion Activation Methods for Peptides and Proteins.Analytical chemistry · 2020Review
- Operation and Performance of a Mass-Selective Cryogenic Linear Ion Trap.Journal of the American Society for Mass Spectrometry · 2018Article
- Article
- Unraveling the unknown areas of the human metabolome: the role of infrared ion spectroscopy.Journal of inherited metabolic disease · 2018Review
- Article
- Magnifying ion mobility spectrometry-mass spectrometry measurements for biomolecular structure studies.Current opinion in chemical biology · 2018Review
- Identification and Partial Structural Characterization of Mass Isolated Valsartan and Its Metabolite with Messenger Tagging Vibrational Spectroscopy.Journal of the American Society for Mass Spectrometry · 2017Article
- Infrared ion spectroscopy inside a mass-selective cryogenic 2D linear ion trap.Journal of mass spectrometry : JMS · 2017Article
- SITS Derivatization of Peptides to Enhance 266 nm Ultraviolet Photodissociation (UVPD).Journal of the American Society for Mass Spectrometry · 2017Article
- Combined Liquid Chromatography-Infrared Ion Spectroscopy for Identification of Regioisomeric Drug Metabolites.Analytical chemistry · 2017Article
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Authors and funding
5 authors.
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Abstract
The detailed chemical information contained in the vibrational spectrum of a cryogenically cooled analyte ion would, in principle, make infrared (IR) ion spectroscopy a gold standard technique for molecular identification in mass spectrometry. Despite this immense potential, there are considerable challenges in both instrumentation and methodology to overcome before the technique is analytically useful. Here, we discuss the promise of IR ion spectroscopy for small molecule analysis in the context of metabolite identification. Experimental strategies to address sensitivity constraints, poor overall duty cycle, and speed of the experiment are intimately tied to the development of a mass-selective cryogenic trap. Therefore, the most likely avenues for success, in the authors' opinion, are presented here, alongside alternative approaches and some thoughts on data interpretation.
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