ReviewBMC research notes2016
A literature review and case report of hand, foot and mouth disease in an immunocompetent adult.
Review in BMC research notes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Population-Level Impact of the Enterovirus A71 Vaccination Program on Hand, Foot, and Mouth Disease: Ecological Time-Series Study.JMIR public health and surveillance · 2026Article
- Development of a novel EV-A71 monoclonal antibody for monitoring vaccine potency.PLoS neglected tropical diseases · 2025Article
- Bee Venom and Its Two Main Components-Melittin and Phospholipase A2-As Promising Antiviral Drug Candidates.Pathogens (Basel, Switzerland) · 2023Review
- Tomato flu outbreak in India.The Lancet. Respiratory medicine · 2023Article
- The emergence of tomato flu: Another pandemic in making?Annals of medicine and surgery (2012) · 2022Article
- Computational Screening of Newly Designed Compounds against Coxsackievirus A16 and Enterovirus A71.Molecules (Basel, Switzerland) · 2022Article
- Global emergence of Enterovirus 71: a systematic review.Beni-Suef University journal of basic and applied sciences · 2022Review
- Hand, Foot, and Mouth Disease: A Narrative Review.Recent advances in inflammation & allergy drug discovery · 2022Review
- Early Evidence of Inactivated Enterovirus 71 Vaccine Impact Against Hand, Foot, and Mouth Disease in a Major Center of Ongoing Transmission in China, 2011-2018: A Longitudinal Surveillance Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Bioinformatics Analysis of Key micro-RNAs and mRNAs under the Hand, Foot, and Mouth Disease Virus Infection.Polish journal of microbiology · 2020Article
- Incidence of Infection of Enterovirus 71 and Coxsackieviruses A6 and A16 among Household Contacts of Index Cases in Dong Thap Province, Southern Vietnam.BioMed research international · 2020Article
- Transcriptomic analysis of cells in response to EV71 infection and 2AGenes & genomics · 2019Article
- Enterovirus A71 Infection Activates Human Immune Responses and Induces Pathological Changes in Humanized Mice.Journal of virology · 2019Article
- Hand, foot and mouth disease in an adult.Infection · 2018Article
- Unraveling the Motions behind Enterovirus 71 Uncoating.Biophysical journal · 2018Article
- Central serous retinopathy and hand-foot-mouth disease: coincidence or causation?International medical case reports journal · 2018Article
- Enterovirus 71 infection and vaccines.Clinical and experimental vaccine research · 2017Review
- Hand, foot and mouth disease (HFMD): A case report.Journal of oral and maxillofacial pathology : JOMFPArticle
- Hand, foot, and mouth disease in adults caused by Coxsackievirus B1-B6.Anais brasileiros de dermatologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo report an uncommon case of hand, foot and mouth disease, (HFMD) in an immunocompetent adult; a highly infectious disease, characterized by the appearance of vesicles on the mouth, hands and feet, associated with coxsackieviruses and enteroviruses; including a literature review. CASE REPORT: A 23 year Caucasian male with no medical or surgical history, no allergies, was not taking any medication and smoked ten cigarettes a day, suffering from discomfort in the oral cavity; itching, burning and pain when swallowing associated with small erythematous lesions located on the hard palate, and small ulcers in tonsillar pillars and right buccal mucosa. Mild fever of 37.8 °C and general malaise. The patient reported he had had contact with a child diagnosed with HFMD. From his background and symptoms, the patient was diagnosed with HFMD. Following symptomatic treatment, the symptoms remitted in 7 days.
methodsA literature review in MEDLINE (PubMed). The inclusion criteria were for studies on humans over the last 5 years, using the keywords HFMD.
resultsWe found 925 articles, which were subsequently reduced to 52 documents after applying the inclusion criteria. Maculopapular lesions were found on hands and feet.
conclusionsDentists may have a key role diagnosing the disease. A surveillance system to predict future outbreaks, encourage early diagnosis, put appropriate public health measures in place and research vaccine development is vitally important in order to control the disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.