ArticleMolecular diversity2016
Ι₂-mediated amination/cyclization of ketones with 2-aminopyridines under high-speed ball milling: solvent- and metal-free synthesis of 2,3-substituted imidazo[1,2-a]pyridines and zolimidine.
Article in Molecular diversity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Ball-mill-assisted mechanochemical approaches for heterocyclic compound synthesis (2015-2024).Molecular diversity · 2026Review
- Imidazo[1,2‑ACS omega · 2026Review
- Scale-Up of Solvent-Free, Mechanochemical Precursor Synthesis for Nanoporous Carbon Materials via Extrusion.ChemSusChem · 2022Article
- Sustainable Solvent-Free Diels-Alder Approaches in the Development of Constructive Heterocycles and Functionalized Materials: A Review.Topics in current chemistry (Cham) · 2022Review
- Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds.SynOpen (2017) · 2022Article
- Ball Milling PromotedMolecules (Basel, Switzerland) · 2018Review
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Authors and funding
4 authors.
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Abstract
Under solvent-free high-speed ball milling, an I[Formula: see text]-promoted condensation/cyclization of easily available methyl ketones or 1,3-dicarbonyl compounds with 2-aminopyridines has been developed, which allows the quick assembly of 2,3-substituted imidazo[1,2-a]pyridines (IPs) with broad molecular diversity, including the antiulcer drug zolimidine. The advantages of high yields, good functional group compatibility, short reaction time (within 90 min), free use of heating, solvent and metal, employment of cheap starting materials, and simple work-up procedure make this protocol a very efficient alternative to traditional synthesis of IPs.
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