ArticleInvestigative ophthalmology & visual science2016
Anatomical Variation of Human Collector Channel Orifices.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Schlemm's Canal Development and Implications for Glaucoma Treatment.Annual review of vision science · 2026Review
- Imaging of aqueous outflow in health and glaucoma. Justifying the re-direction of aqueous.Eye (London, England) · 2025Review
- A Histomorphometric and Computational Investigation of the Stabilizing Role of Pectinate Ligaments in the Aqueous Outflow Pathway.Journal of biomechanical engineering · 2024Article
- A Histomorphometric and Computational Investigation of the Stabilizing Role of Pectinate Ligaments in the Aqueous Outflow Pathway.bioRxiv : the preprint server for biology · 2024Article
- Pathological Mechanism and Clinical Therapy Progress of Schlemm's Canal.Journal of ophthalmology · 2024Review
- Descemet's Membrane Detachment during Phacocanaloplasty: Case Series and In-Depth Literature Review.Journal of clinical medicine · 2023Article
- Pressure Clamping During Ocular Perfusions Drives Nitric Oxide-Mediated Washout.Investigative ophthalmology & visual science · 2023Article
- Evaluation of neural innervation in the human conventional outflow pathway distal to Schlemm's canal.Experimental eye research · 2022Review
- Valve-Like Outflow System Behavior With Motion Slowing in Glaucoma Eyes: Findings Using a Minimally Invasive Glaucoma Surgery-MIGS-Like Platform and Optical Coherence Tomography Imaging.Frontiers in medicine · 2022Article
- Modeling the effects of glaucoma surgery on intraocular pressure.Experimental eye research · 2021Article
- Aqueous outflow regulation - 21st century concepts.Progress in retinal and eye research · 2021Review
- Effects of Schlemm's Canal Expansion: Biomechanics and MIGS Implications.Life (Basel, Switzerland) · 2021Article
- Aqueous outflow imaging techniques and what they tell us about intraocular pressure regulation.Eye (London, England) · 2021Review
- Segmental differences found in aqueous angiographic-determined high - and low-flow regions of human trabecular meshwork.Experimental eye research · 2020Article
- Tissue-Engineered Models for Glaucoma Research.Micromachines · 2020Review
- Shear Stress in Schlemm's Canal as a Sensor of Intraocular Pressure.Scientific reports · 2020Article
- 3D-Reconstruction of the human conventional outflow system by ribbon scanning confocal microscopy.PloS one · 2020Article
- Progress in the basic and clinical research on the Schlemm's canal.International journal of ophthalmology · 2020Review
- Fluorescein Aqueous Angiography in Live Normal Human Eyes.Journal of glaucoma · 2018Article
- Pharmacological regulation of outflow resistance distal to Schlemm's canal.American journal of physiology. Cell physiology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purposeTo examine the anatomical variation of normal human collector channel orifices and their relationship with Schlemm's canal.
methodsTen human anterior segments fixed by immersion or perfusion were dissected radially and further divided by fine dissection into corresponding inner and outer wall segments. The tissues were dehydrated, critical-point dried, sputter coated, and examined by scanning electron microscopy. Images were obtained at magnifications from ×200 to ×10,000. Selected radial collector channel regions were processed for plastic embedding.
resultsTwo classes of collector channel orifices were identified. Simple oval orifices (54.7 ± 4.6-μm diameter) were lined with endothelial cells and most often occurred on a planar region of Schlemm's canal outer wall. Complex orifices (62.7 ± 3.4-μm diameter) were often found associated with septal columns and bridges, and typically covered with flap-like structures (10-40 μm) that extended between the inner and outer wall and over the collector channel orifices. Both simple and complex orifices had complete or partial lip-like rims. In orifices with partial rims, a trough-like groove was often visible on the outer wall surface opposite the lip. Transected septa and inner and outer wall adhesion sites were often found in association with complex collector channel orifices.
conclusionsCollector channel orifice structure varied from simple ovals to complex tethered flaps and bridges. Collector channel orifices with complex flaps connect the inner and outer walls of Schlemm's canal, and may serve to enhance and regulate aqueous outflow in these regions.
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