ArticlePLoS pathogens2016
Cellular Tracking and Gene Profiling of Fusarium graminearum during Maize Stalk Rot Disease Development Elucidates Its Strategies in Confronting Phosphorus Limitation in the Host Apoplast.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 108 citations in OpenAlex.
- ZmWRKY29 Transcriptionally Represses ZmRBOHC to Attenuate ROS Production and Facilitates Gibberella Stalk Rot Susceptibility in Maize.Plant biotechnology journal · 2026Article
- The Zma-miRNA319-ZmMYB74 Module Regulates Maize Resistance to Stalk Rot Disease by Modulating Lignin Deposition.Plant biotechnology journal · 2026Article
- Arabinoxylan and pectin features differentiate maize inbred lines with contrasting Fusarium stalk rot resistance.Frontiers in plant science · 2026Article
- Laccaria bicolor adapts to phosphate deficiency at the developmental, transcriptional and metabolic levels.Mycorrhiza · 2025Article
- Effects ofFoods (Basel, Switzerland) · 2025Article
- Integrative perspectives on glycosylation networks in fungi and oomycetes.Journal of microbiology (Seoul, Korea) · 2025Review
- Article
- Article
- Genetic and Genomic Tools in Breeding for Resistance to Fusarium Stalk Rot in Maize (Plants (Basel, Switzerland) · 2025Review
- Soil microbiome bacteria protect plants against filamentous fungal infections via intercellular contacts.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Specific Transcriptional Regulation Controls Plant Organ-Specific Infection by the Oomycete Pathogen Phytophthora sojae.Molecular plant pathology · 2024Article
- Article
- Single-cell RNA sequencing profiles reveal cell type-specific transcriptional regulation networks conditioning fungal invasion in maize roots.Plant biotechnology journal · 2023Article
- Rhizobial nitrogen fixation efficiency shapes endosphere bacterial communities and Medicago truncatula host growth.Microbiome · 2023Article
- Integrative transcriptome and proteome analysis reveals maize responses to Fusarium verticillioides infection inside the stalks.Molecular plant pathology · 2023Article
- Lipidomics Analysis of Multilamellar Bodies Produced by AmoebaPathogens (Basel, Switzerland) · 2023Article
- Genome-wide association study of maize resistance toFrontiers in plant science · 2023Article
- Sgh1, an SR-like Protein, Is Involved in Fungal Development, Plant Infection, and Pre-mRNA Processing inJournal of fungi (Basel, Switzerland) · 2022Article
- Unveiling the Core Effector Proteins of Oil Palm PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- Identification of Candidate Genes Associated with Trichothecene Biosynthesis inMicroorganisms · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The ascomycete fungus Fusarium graminearum causes stalk rot in maize. We tracked this pathogen's growth in wound-inoculated maize stalks using a fluorescence-labeled fungal isolate and observed that invasive hyphae grew intercellularly up to 24 h post inoculation, grew intra- and inter-cellularly between 36-48 h, and fully occupied invaded cells after 72 h. Using laser microdissection and microarray analysis, we profiled changes in global gene expression during pathogen growth inside pith tissues of maize stalk from 12 h to six days after inoculation and documented transcriptomic patterns that provide further insights into the infection process. Expression changes in transcripts encoding various plant cell wall degrading enzymes appeared to correlate with inter- and intracellular hyphal growth. Genes associated with 36 secondary metabolite biosynthesis clusters were expressed. Expression of several F. graminearum genes potentially involved in mobilization of the storage lipid triacylglycerol and phosphorus-free lipid biosynthesis were induced during early infection time points, and deletion of these genes caused reduction of virulence in maize stalk. Furthermore, we demonstrated that the F. graminearum betaine lipid synthase 1 (BTA1) gene was necessary and sufficient for production of phosphorus-free membrane lipids, and that deletion of BTA1 interfered with F. graminearum's ability to advance intercellularly. We conclude that F. graminearum produces phosphorus-free membrane lipids to adapt to a phosphate-limited extracellular microenvironment during early stages of its invasion of maize stalk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.