Evidence map›Paper›PMID 26974957›Full record

ArticleNature nanotechnology2016

Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice.

Xue Xue, Jing-Yu Yang, Yi He, Li-Rong Wang, Ping Liu, Li-Sha Yu, Guo-Hua Bi, Ming-Ming Zhu, Yue-Yang Liu, Rong-Wu Xiang and 11 more

Open access · greenAbstract read
In one paragraph

Article in Nature nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 92 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Carbon Dots Derived from Os Draconis and Their Anxiolytic Effect.International journal of nanomedicine · 2022
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  7. Review
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  11. Article
  12. Article
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  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Nanomedicine: Going small to beat the high.Nature nanotechnology · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Xue XueCAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.
Jing-Yu YangDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yi HeIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
Li-Rong WangCAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.
Ping LiuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li-Sha YuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Guo-Hua BiIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
Ming-Ming ZhuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yue-Yang LiuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Rong-Wu XiangDepartment of Biopharmaceutical Information, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xiao-Ting YangDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xin-Yu FanDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xiao-Min WangDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jia QiIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
Hong-Jie ZhangState Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Tuo WeiCAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.
Wei CuiDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Guang-Lu GeCAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.
Zheng-Xiong XiIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
Chun-Fu WuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xing-Jie LiangCAS Center for Excellence in Nanoscience, Chinese Academy of Sciences and National Center for Nanoscience and Technology of China, Beijing 100190, China.
Shenyang Pharmaceutical University · CNNational Center for Nanoscience and Technology · CNChinese Academy of Sciences · CNNational Institute on Drug Abuse · USNational Institutes of Health · US

Funding

Basic brain mechanisms underlying drug addiction, craving, and relapseZIADA000478 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI GARDNER, ELIOT · 2009 to 2023
$7.9M
Intramural NIH HHS Z99 DA999999
6 · The paper itself

Abstract

Methamphetamine (METH) abuse is a serious social and health problem worldwide. At present, there are no effective medications to treat METH addiction. Here, we report that aggregated single-walled carbon nanotubes (aSWNTs) significantly inhibited METH self-administration, METH-induced conditioned place preference and METH- or cue-induced relapse to drug-seeking behaviour in mice. The use of aSWNTs alone did not significantly alter the mesolimbic dopamine system, whereas pretreatment with aSWNTs attenuated METH-induced increases in extracellular dopamine in the ventral striatum. Electrochemical assays suggest that aSWNTs facilitated dopamine oxidation. In addition, aSWNTs attenuated METH-induced increases in tyrosine hydroxylase or synaptic protein expression. These findings suggest that aSWNTs may have therapeutic effects for treatment of METH addiction by oxidation of METH-enhanced extracellular dopamine in the striatum.

Indexed as

Nanotubes, CarbonAnimalsBehavior, AnimalBody WeightCorpus StriatumDopamineDopamine Plasma Membrane Transport ProteinsEatingMaleMethamphetamineMiceMice, Inbred C57BLProtein BindingTyrosine 3-MonooxygenaseDopamineDopamine Plasma Membrane Transport ProteinsMethamphetamineNanotubes, CarbonTyrosine 3-Monooxygenase

Identifiers

PMID26974957
PMCPMC5535299
OpenAlexW2302175434

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.