ArticlePloS one2016
Quantitative Susceptibility Mapping-Based Microscopy of Magnetic Resonance Venography (QSM-mMRV) for In Vivo Morphologically and Functionally Assessing Cerebromicrovasculature in Rat Stroke Model.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Quantitative MRI Susceptibility: Mapping of Transient Ischemic Attack-A Preliminary Study.Journal of imaging · 2026Article
- Iron changes within infarct tissue in ischemic stroke patients after successful reperfusion quantified using QSM.Neuroradiology · 2024Article
- Recommended implementation of quantitative susceptibility mapping for clinical research in the brain: A consensus of the ISMRM electro-magnetic tissue properties study group.Magnetic resonance in medicine · 2024Article
- In vivo mapping of hippocampal venous vasculature and oxygenation using susceptibility imaging at 7T.NeuroImage · 2024Article
- Modeling venous bias in resting state functional MRI metrics.Human brain mapping · 2023Article
- Cerebral oxygen metabolism from MRI susceptibility.NeuroImage · 2023Review
- Quantitative Evaluation of Oxygen Extraction Fraction Changes in the Monkey Brain during Acute Stroke by Using Quantitative Susceptibility Mapping.Life (Basel, Switzerland) · 2023Article
- Quantitative Distribution of Cerebral Venous Oxygen Saturation and Its Prognostic Value in Patients with Acute Ischemic Stroke.Brain sciences · 2022Article
- A Novel Rodent Model of Hypertensive Cerebral Small Vessel Disease with White Matter Hyperintensities and Peripheral Oxidative Stress.International journal of molecular sciences · 2022Article
- Quantitative susceptibility mapping as a measure of cerebral oxygenation in neonatal piglets.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization.Scientific reports · 2021Article
- Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations.Diagnostics (Basel, Switzerland) · 2021Review
- Phase unwrapping with a rapid opensource minimum spanning tree algorithm (ROMEO).Magnetic resonance in medicine · 2021Article
- QSM in canine model of acute cerebral ischemia: A pilot study.Magnetic resonance in medicine · 2021Article
- Comparison of Phase Estimation Methods for Quantitative Susceptibility Mapping Using a Rotating-Tube Phantom.Radiology research and practice · 2021Article
- Microcirculatory Changes in Experimental Models of Stroke and CNS-Injury Induced Immunodepression.International journal of molecular sciences · 2019Review
- Vascular and Tissue Changes of Magnetic Susceptibility in the Mouse Brain After Transient Cerebral Ischemia.Translational stroke research · 2018Article
- Reduced deep regional cerebral venous oxygen saturation in hemodialysis patients using quantitative susceptibility mapping.Metabolic brain disease · 2018Article
- Decreased oxygen saturation levels in neonates with transposition of great arteries: Impact on appearance of cerebral veins in susceptibility-weighted imaging.Scientific reports · 2017Article
- Decreased susceptibility of major veins in mild traumatic brain injury is correlated with post-concussive symptoms: A quantitative susceptibility mapping study.NeuroImage. Clinical · 2017Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal cerebral oxygenation and vessel structure is a crucial feature of stroke. An imaging method with structural and functional information is necessary for diagnosis of stroke. This study applies QSM-mMRV (quantitative susceptibility mapping-based microscopic magnetic resonance venography) for noninvasively detecting small cerebral venous vessels in rat stroke model. First, susceptibility mapping is optimized and calculated from magnetic resonance (MR) phase images of a rat brain. Subsequently, QSM-mMRV is used to simultaneously provide information on microvascular architecture and venous oxygen saturation (SvO2), both of which can be used to evaluate the physiological and functional characteristics of microvascular changes for longitudinally monitoring and therapeutically evaluating a disease model. Morphologically, the quantification of vessel sizes using QSM-mMRV was 30% smaller than that of susceptibility-weighted imaging (SWI), which eliminated the overestimation of conventional SWI. Functionally, QSM-mMRV estimated an average SvO2 ranging from 73% to 85% for healthy rats. Finally, we also applied QSM to monitor the revascularization of post-stroke vessels from 3 to 10 days after reperfusion. QSM estimations of SvO2 were comparable to those calculated using the pulse oximeter standard metric. We conclude that QSM-mMRV is useful for longitudinally monitoring blood oxygen and might become clinically useful for assessing cerebrovascular diseases.
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