ArticleNature chemical biology2016
Light-controlled modulation of gene expression by chemical optoepigenetic probes.
Article in Nature chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 87 citations in OpenAlex.
- Light-controlled inhibition of Gram-positive bacteria by photoswitchable amphiphilic lipids (PALs).RSC medicinal chemistry · 2026Article
- Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch.Nature chemistry · 2025Article
- Augmenting the Anti-Leukemic Activity of the BCL-2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL-2/HDAC1 and Dual BCL-2/HDAC6 Inhibitors.Drug development research · 2025Article
- Opto-Epigenetic Regulation of Histone Arginine Asymmetric Dimethylation via Type I Protein Arginine Methyltransferase Inhibition.Journal of medicinal chemistry · 2025Article
- Emerging RNAi Therapies to Treat Hypertension.Molecular diagnosis & therapy · 2025Review
- Control of metalloenzyme activity using photopharmacophores.Coordination chemistry reviews · 2024Article
- Visible-Light-Controlled Histone Deacetylase Inhibitors for Targeted Cancer Therapy.Journal of medicinal chemistry · 2023Article
- Photoresponsive Small Molecule Inhibitors for the Remote Control of Enzyme Activity.Chemistry, an Asian journal · 2022Review
- Development and Characterization of Light-Responsive Peptide Macrocycles.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Review
- A Photodeactivatable Antagonist for Controlling CREB-Dependent Gene Expression.ACS central science · 2020Article
- Activation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility.ChemMedChem · 2020Article
- An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment.Science advances · 2020Article
- Using Remote Fields for Complex Tissue Engineering.Trends in biotechnology · 2020Review
- NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices.Nature communications · 2019Article
- A Photo-responsive Small-Molecule Approach for the Opto-epigenetic Modulation of DNA Methylation.Angewandte Chemie (International ed. in English) · 2019Article
- A Singular System with Precise Dosing and Spatiotemporal Control of CRISPR-Cas9.Angewandte Chemie (International ed. in English) · 2019Article
- Molecular Mechanisms of the Memory Trace.Trends in neurosciences · 2019Review
- Clinicopathological features and prediction values of HDAC1, HDAC2, HDAC3, and HDAC11 in classical Hodgkin lymphoma.Anti-cancer drugs · 2018Article
- Optochemical Control of Biological Processes in Cells and Animals.Angewandte Chemie (International ed. in English) · 2018Review
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
Epigenetic gene regulation is a dynamic process orchestrated by chromatin-modifying enzymes. Many of these master regulators exert their function through covalent modification of DNA and histone proteins. Aberrant epigenetic processes have been implicated in the pathophysiology of multiple human diseases. Small-molecule inhibitors have been essential to advancing our understanding of the underlying molecular mechanisms of epigenetic processes. However, the resolution offered by small molecules is often insufficient to manipulate epigenetic processes with high spatiotemporal control. Here we present a generalizable approach, referred to as 'chemo-optical modulation of epigenetically regulated transcription' (COMET), enabling high-resolution, optical control of epigenetic mechanisms based on photochromic inhibitors of human histone deacetylases using visible light. COMET probes may be translated into new therapeutic strategies for diseases where conditional and selective epigenome modulation is required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.