ArticlePloS one2016
Distinct Clinical Characteristics of Pediatric Guillain-Barré Syndrome: A Comparative Study between Children and Adults in Northeast China.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Guillain-Barré Syndrome After Inactivated Poliovirus Vaccination: A Rare Clinical Case Report.Annals of medicine and surgery (2012) · 2025Article
- Serial Serum Immunoglobulin G Levels and Correlation with Outcomes in Children with Guillain Barre Syndrome.Indian journal of pediatrics · 2025Observational
- Pediatric Cardiac Arrest Secondary to Guillain-Barré Syndrome-Induced Dysautonomia.Children (Basel, Switzerland) · 2025Article
- Clinico-epidemiological profile and prediction of outcome in children with Guillain-Barre syndrome.Italian journal of pediatrics · 2025Observational
- Hyperreflexia and Preserved Reflexes in Pediatric Guillain-Barré Syndrome: A Case Report and Literature Review.Cureus · 2025Article
- Clinical characteristics and functional outcomes of pediatric Guillain-Barré syndrome admitted to the Neuro-intensive care unit: a decade-long retrospective observational study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Observational
- Correlation between Electrodiagnostic Findings and Cerebrospinal Fluid Changes in Children with Guillain-Barre syndrome.Iranian journal of child neurology · 2025Article
- SARS-CoV-2-related Guillain-Barre syndrome with cranial nerve involvement can be easily mistaken for Miller-Fisher syndrome.Journal of family medicine and primary care · 2023Article
- Pediatric Guillain-Barré Syndrome in a Resource Limited Setting: Clinical Features, Diagnostic and Management Challenges, and Hospital Outcome.Pediatric health, medicine and therapeutics · 2023Article
- Guillain-Barré Syndrome in Northern China: A Retrospective Analysis of 294 Patients from 2015 to 2020.Journal of clinical medicine · 2022Article
- Article
- Regional Differences of Guillain-Barré Syndrome in China: From South to North.Frontiers in aging neuroscience · 2022Article
- Clinical Outcome of Guillain-Barré Syndrome in 108 Children.Indian pediatrics · 2021Article
- [Clinical features of children with Guillain-Barré syndrome and the significance of Brighton criteria].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Epidemiology of Guillain-Barré Syndrome in Iranian Children Aged 0-15 Years (2008-2013).Iranian journal of child neurology · 2021Article
- Successful treatment of a 12-year-old boy with Guillain-Barré syndrome requiring tracheostomy due to respiratory muscle paralysis: A case report.Experimental and therapeutic medicine · 2020Article
- A Predictive Model for Respiratory Failure and Determining the Risk Factors of Prolonged Mechanical Ventilation in Children with Guillain-Barre Syndrome.Iranian journal of child neurology · 2020Article
- Initial Response and Outcome of Critically Ill Children With Guillain Barre' Syndrome.Frontiers in pediatrics · 2019Article
- Case report: Guillain-Barre syndrome with pneumococcus - A new association in pediatrics.IDCases · 2018Article
- Predictive factors for achieving independent walking in children with Guillain-Barre syndrome.Pediatric research · 2017Observational
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
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Abstract
objectiveClinical characteristics of pediatric Guillain-Barré syndrome (GBS) have been extensively studied whereas scarcely been compared with those of adult GBS. Herein we compared the clinical features of GBS between pediatric and adult patients.
methodsWe retrospectively collected the clinical data of 750 patients with GBS (541 adults and 209 children), and compared the clinical characteristics between children and adults.
resultsPain was a more frequent complaint in children (17.2% vs 9.6%, p < 0.01), who were also found with shorter interval from disease onset to nadir (6.3d vs 7.3d, p < 0.01) and higher incidence of bulbar dysfunction (22.0% vs 14.8%, p < 0.05). The disease severity in children was comparable with adults. In addition, a higher incidence of pediatric GBS was found in summer, especially in July and August (both p < 0.01). However, the incidence of antecedent infections of different seasons in adult and pediatric patients was comparable (p > 0.05). The clinical features of acute motor axonal neuropathy (AMAN) and acute inflammatory demyelinating polyneuropathy (AIDP) in children were overall comparable with adult ones (p > 0.05). Similar to adults, bulbar dysfunction (odds ratio [OR]: 4.621, 95% confidence interval [CI]: 1.240-17.218, p < 0.05) and lower nadir Medical Research Council (MRC) sum score (OR: 0.897, 95% CI: 0.855-0.941, p < 0.01) were also risk factors for mechanical ventilation in children. However, distinct from adult ones, autonomic dysfunction was significantly higher in mechanically ventilated childhood GBS (39.1% vs 8.8%, p < 0.01), which also served as a predictor for mechanical ventilation in pediatric GBS (OR: 70.415, 95% CI: 9.265-535.158, p < 0.01). As to the efficacy of intravenous immunoglobulin, insignificant difference was identified between children and adults.
conclusionThe clinical features of pediatric GBS differ from those of adults. Autonomic dysfunction is an independent risk factor for mechanical ventilation in pediatric patients.
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