Evidence map›Paper›PMID 26974654›Full record

Trial reportPloS one2016

Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation.

Arielle Y Zahavi, Mark A Sabbagh, Dustin Washburn, Raegan Mazurka, R Michael Bagby, John Strauss, James L Kennedy, Arun Ravindran, Kate L Harkness

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. An eye-tracking controlled neuropsychological battery for cognitive assessment in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Arielle Y ZahaviDepartment of Psychology, Queen's University, Kingston, Ontario, Canada.
Mark A SabbaghDepartment of Psychology, Queen's University, Kingston, Ontario, Canada.
Dustin WashburnDepartment of Psychology, Queen's University, Kingston, Ontario, Canada.
Raegan MazurkaDepartment of Psychology, Queen's University, Kingston, Ontario, Canada.
R Michael BagbyDepartment of Psychology, University of Toronto Scarborough, Toronto, Ontario, Canada.
John StraussCentre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
James L KennedyCentre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
Arun RavindranCentre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
Kate L HarknessDepartment of Psychology, Queen's University, Kingston, Ontario, Canada.
Queen's University · CAUniversity of Toronto · CACentre for Addiction and Mental Health · CA

Funding

Canadian Institutes of Health Research 79320
6 · The paper itself

Abstract

Theory of mind-the ability to decode and reason about others' mental states-is a universal human skill and forms the basis of social cognition. Theory of mind accuracy is impaired in clinical conditions evidencing social impairment, including major depressive disorder. The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4), dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and catechol-O-methyl transferase (COMT) genes with theory of mind decoding in a sample of adults with major depression. Ninety-six young adults (38 depressed, 58 non-depressed) completed the 'Reading the Mind in the Eyes task' and a non-mentalistic control task. Genetic associations were only found for the depressed group. Specifically, superior accuracy in decoding mental states of a positive valence was seen in those homozygous for the long allele of the serotonin transporter gene, 9-allele carriers of DAT1, and long-allele carriers of DRD4. In contrast, superior accuracy in decoding mental states of a negative valence was seen in short-allele carriers of the serotonin transporter gene and 10/10 homozygotes of DAT1. Results are discussed in terms of their implications for integrating social cognitive and neurobiological models of etiology in major depression.

Indexed as

AllelesCognitionPolymorphism, GeneticAdultCatechol O-MethyltransferaseDepressionDopamineDopamine Plasma Membrane Transport ProteinsFemaleHumansMaleReceptors, Dopamine D4SerotoninSerotonin Plasma Membrane Transport ProteinsCatechol O-MethyltransferaseCOMT protein, humanDopamineDopamine Plasma Membrane Transport ProteinsDRD4 protein, humanReceptors, Dopamine D4SerotoninSerotonin Plasma Membrane Transport ProteinsSLC6A3 protein, humanSLC6A4 protein, human

Identifiers

PMID26974654
PMCPMC4790964
OpenAlexW2298248335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.