Evidence map›Paper›PMID 26974604›Full record

ArticleJournal of natural products2016

Cyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa.

Nuraqilah Othman, Li Pan, Michele Mejin, Julian C L Voong, Hee-byung Chai, Caroline M Pannell, A Douglas Kinghorn, Tiong C Yeo

Abstract read
In one paragraph

Article in Journal of natural products, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Comparative phytochemistry of flavaglines (= rocaglamides), a group of highly bioactive flavolignans fromPhytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022
    Review
  8. Review
  9. Structurally Modified Cyclopenta[Journal of natural products · 2019
    Article
  10. Review
  11. The Search for Anticancer Agents from Tropical Plants.Progress in the chemistry of organic natural products
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nuraqilah OthmanSarawak Biodiversity Centre , KM20, Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, Kuching 93990, Sarawak Malaysia.
Li PanDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio 43210, United States.
Michele MejinSarawak Biodiversity Centre , KM20, Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, Kuching 93990, Sarawak Malaysia.
Julian C L VoongSarawak Biodiversity Centre , KM20, Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, Kuching 93990, Sarawak Malaysia.
Hee-byung ChaiDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio 43210, United States.
Caroline M PannellDepartment of Plant Sciences, University of Oxford , South Parks Road, Oxford OX1 3RB, United Kingdom.
A Douglas KinghornDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio 43210, United States.
Tiong C YeoSarawak Biodiversity Centre , KM20, Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, Kuching 93990, Sarawak Malaysia.

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JAMES R FUCHS · 2007 to 2026
$27.2M
NCI NIH HHS P01 CA125066NCI NIH HHS P01CA125066
6 · The paper itself

Abstract

Four new 2,3-secodammarane triterpenoids, stellatonins A-D (3-6), together with a new 3,4-secodammarane triterpenoid, stellatonin E (7), and the known silvestrol (1), 5‴-episilvestrol (2), and β-sitosterol, were isolated from a methanol extract of the stems of Aglaia stellatopilosa through bioassay-guided fractionation. The structures of the new compounds were elucidated using spectroscopic and chemical methods. The compounds were evaluated for their cytotoxic activity against three human cancer cell lines and for their antimicrobial activity using a microtiter plate assay against a panel of Gram-positive and Gram-negative bacteria and fungi.

Indexed as

AglaiaAntineoplastic Agents, PhytogenicBenzofuransDammaranesDrug Screening Assays, AntitumorFemaleGram-Negative BacteriaGram-Positive BacteriaHT29 CellsHumansMalaysiaMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant StemsSaccharomyces cerevisiaeAntineoplastic Agents, PhytogenicBenzofuransDammaranesepisilvestrolgamma-sitosterolsilvestrolSitosterolsstellatonin ETriterpenes

Identifiers

PMID26974604
PMCPMC4841703

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.