Systematic Bias in Meta-Analyses of Time to Antimicrobial in Sepsis Studies.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. [S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020
   Guideline
2. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.Intensive care medicine · 2017
   Guideline
3. Duration of antibiotic therapy in critically ill patients: a randomized controlled trial of a clinical and C-reactive protein-based protocol versus an evidence-based best practice strategy without biomarkers.Critical care (London, England) · 2020
   Trial
4. A Multicenter Clinical Study To Demonstrate the Diagnostic Accuracy of the GenMark Dx ePlex Blood Culture Identification Gram-Negative Panel.Journal of clinical microbiology · 2021
   Article
5. Compliance with the Surviving Sepsis Campaign guideline 1-hour bundle for septic shock in China in 2018.Annals of translational medicine · 2021
   Article
6. Sepsis-Pathophysiology and Therapeutic Concepts.Frontiers in medicine · 2021
   Review
7. Epidemiology and risk factors of candidemia due to Candida parapsilosis in an intensive care unit.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021
   Article
8. Prevalence and Prognostic Impact of Hypernatremia in Sepsis and Septic Shock Patients in the Intensive Care Unit: A Single Centre Experience.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2020
   Article
9. Rules of anti-infection therapy for sepsis and septic shock.Chinese medical journal · 2019
   Review
10. The Surviving Sepsis Campaign Bundle: 2018 update.Intensive care medicine · 2018
    Article
11. The authors reply.Critical care medicine · 2016
    Article
12. Imipenem-induced paroxysmal supraventricular tachycardia in a sepsis patient.Journal of anaesthesiology, clinical pharmacology
    Article

Corrections and comments

• Commented on by
  The authors reply.2016
• Comment on
  The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis.2015

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as