ArticlePloS one2016
Seeking Optimal Region-Of-Interest (ROI) Single-Value Summary Measures for fMRI Studies in Imaging Genetics.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.Psychiatry research. Neuroimaging · 2024Trial
- Individual differences in brain systems supporting declarative and procedural memory during grammatical error processing in children.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- DrSVision: A Machine Learning Tool for Cortical Region-Specific fNIRS Calibration Based on Cadaveric Head MRI.Sensors (Basel, Switzerland) · 2025Article
- Long-term musical training can protect against age-related upregulation of neural activity in speech-in-noise perception.PLoS biology · 2025Article
- Genetic risk for schizophrenia and brain activation during the Penn Conditional Exclusion Test: A multiplex extended pedigree study.Journal of psychopathology and clinical science · 2025Article
- A Statistical Characterization of Dynamic Brain Functional Connectivity.Human brain mapping · 2025Article
- Task-based effective connectivity finds alterations in frontoparietal network in Duchenne muscular dystrophy.Brain communications · 2025Article
- Non-invasive neuromodulation of the right temporoparietal junction using theta-burst stimulation in functional neurological disorder.BMJ neurology open · 2024Article
- Refocus on stopping! Replication of reduced right amygdala reactivity to negative, visual primes during inhibition of motor responses.Neuroimage. Reports · 2023Article
- The stress-buffering role of friendships in young people with childhood threat experiences: a preliminary report.European journal of psychotraumatology · 2023Article
- Similar neural networks respond to coherence during comprehension and production of discourse.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Neural pathways of phonological and semantic processing and its relations to children's reading skills.Frontiers in neuroscience · 2022Article
- Exploring brain connectivity changes in major depressive disorder using functional-structural data fusion: A CAN-BIND-1 study.Human brain mapping · 2021Article
- Article
- Letter fluency in 7-8-year-old children is related to the anterior, but not posterior, ventral occipito-temporal cortex during an auditory phonological task.Developmental cognitive neuroscience · 2021Article
- Neurofeedback Training of Auditory Selective Attention Enhances Speech-In-Noise Perception.Frontiers in human neuroscience · 2021Article
- Effect of noise and estimator type on bias for analysis of liver proton density fat fraction.Magnetic resonance imaging · 2020Article
- Healthy women with severe early life trauma show altered neural facilitation of emotion inhibition under acute stress.Psychological medicine · 2020Article
- Assessment of cortical reorganization and preserved function in phantom limb pain: a methodological perspective.Scientific reports · 2020Article
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Authors and funding
8 authors.
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Abstract
A data-driven hypothesis-free genome-wide association (GWA) approach in imaging genetics studies allows screening the entire genome to discover novel genes that modulate brain structure, chemistry, and function. However, a whole brain voxel-wise analysis approach in such genome-wide based imaging genetic studies can be computationally intense and also likely has low statistical power since a stringent multiple comparisons correction is needed for searching over the entire genome and brain. In imaging genetics with functional magnetic resonance imaging (fMRI) phenotypes, since many experimental paradigms activate focal regions that can be pre-specified based on a priori knowledge, reducing the voxel-wise search to single-value summary measures within a priori ROIs could prove efficient and promising. The goal of this investigation is to evaluate the sensitivity and reliability of different single-value ROI summary measures and provide guidance in future work. Four different fMRI databases were tested and comparisons across different groups (patients with schizophrenia, their siblings, vs. normal control subjects; across genotype groups) were conducted. Our results show that four of these measures, particularly those that represent values from the top most-activated voxels within an ROI are more powerful at reliably detecting group differences and generating greater effect sizes than the others.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.