ArticleeLife2016
Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Stochastic growth and ligand-receptor interaction-mediated stabilization generate stereotyped dendritic arbors.Nature neuroscience · 2026Article
- Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans.Biology open · 2026Article
- A dendritic guidance receptor functions in both ligand dependent and independent modes.PLoS genetics · 2025Article
- Expansion of lysosomal capacity in early adult neurons driven by TFEB/HLH-30 protects dendrite maintenance during aging in Caenorhabditis elegans.PLoS biology · 2025Article
- A dendritic guidance receptor functions in both ligand dependent and independent modes.bioRxiv : the preprint server for biology · 2025Article
- A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping.Nature communications · 2024Article
- Endocytosis restricts dendrite branching via removing ectopically localized branching ligands.Nature communications · 2024Article
- The kpc-1 3'UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship.PLoS genetics · 2024Article
- Dendrite morphogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Endoplasmic Reticulum Exit Sites scale with somato-dendritic size in neurons.Molecular biology of the cell · 2023Article
- Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion.Development (Cambridge, England) · 2023Article
- Two intrinsic timing mechanisms set start and end times for dendritic arborization of a nociceptive neuron.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The emerging role of furin in neurodegenerative and neuropsychiatric diseases.Translational neurodegeneration · 2022Review
- Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning.EMBO reports · 2022Article
- Article
- Neuron tracing and quantitative analyses of dendritic architecture reveal symmetrical three-way-junctions and phenotypes of git-1 in C. elegans.PLoS computational biology · 2021Article
- The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning.PLoS genetics · 2021Article
- Tetris in the Nervous System: What Principles of Neuronal Tiling Can Tell Us About How Glia Play the Game.Frontiers in cellular neuroscience · 2021Review
- Deep learning-enabled analysis reveals distinct neuronal phenotypes induced by aging and cold-shock.BMC biology · 2020Article
- Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.PLoS genetics · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Extracellular adhesion molecules and their neuronal receptors guide the growth and branching of axons and dendrites. Growth cones are attracted to intermediate targets, but they must switch their response upon arrival so that they can move away and complete the next stage of growth. Here, we show that KPC-1, a C. elegans Furin homolog, regulates the level of the branching receptor DMA-1 on dendrites by targeting it to late endosomes. In kpc-1 mutants, the level of DMA-1 is abnormally high on dendrites, resulting in trapping of dendrites at locations where a high level of the cognate ligand, the adhesion molecule SAX-7/L1, is present. The misregulation of DMA-1 also causes dendritic self-avoidance defects. Thus, precise regulation of guidance receptors creates flexibility of responses to guidance signals and is critical for neuronal morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.