ArticlePloS one2016
Transcription Factors Expressed in Mouse Cochlear Inner and Outer Hair Cells.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Optimized in vivo base editing restores auditory function in a DFNA15 mouse model.Nature communications · 2025Article
- Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea.Molecular biology and evolution · 2023Article
- Article
- Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells.Cell reports · 2022Article
- Mapping the regulatory landscape of auditory hair cells from single-cell multi-omics data.Genome research · 2021Article
- Fursultiamine Prevents Drug-Induced Ototoxicity by Reducing Accumulation of Reactive Oxygen Species in Mouse Cochlea.Antioxidants (Basel, Switzerland) · 2021Article
- Transcription co-factor LBH is necessary for the survival of cochlear hair cells.Journal of cell science · 2021Article
- Deletion of Clusterin Protects Cochlear Hair Cells against Hair Cell Aging and Ototoxicity.Neural plasticity · 2021Article
- TUB and ZNF532 Promote the Atoh1-Mediated Hair Cell Regeneration in Mouse Cochleae.Frontiers in cellular neuroscience · 2021Article
- Consumption of betel quid contributes to sensorineural hearing impairment through arecoline-induced oxidative stress.Scientific reports · 2019Article
- Article
- Transcriptomes of cochlear inner and outer hair cells from adult mice.Scientific data · 2018Article
- RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells.Scientific data · 2018Article
- Cell-Specific Transcriptome Analysis Shows That Adult Pillar and Deiters' Cells Express Genes Encoding Machinery for Specializations of Cochlear Hair Cells.Frontiers in molecular neuroscience · 2018Article
- Intracellular Regulome Variability Along the Organ of Corti: Evidence, Approaches, Challenges, and Perspective.Frontiers in genetics · 2018Review
- Apoptosis in inner ear sensory hair cells.Journal of otology · 2017Review
- Article
- A Novel Nonsense Mutation ofNeural plasticity · 2016Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Regulation of gene expression is essential to determining the functional complexity and morphological diversity seen among different cells. Transcriptional regulation is a crucial step in gene expression regulation because the genetic information is directly read from DNA by sequence-specific transcription factors (TFs). Although several mouse TF databases created from genome sequences and transcriptomes are available, a cell type-specific TF database from any normal cell populations is still lacking. We identify cell type-specific TF genes expressed in cochlear inner hair cells (IHCs) and outer hair cells (OHCs) using hair cell-specific transcriptomes from adult mice. IHCs and OHCs are the two types of sensory receptor cells in the mammalian cochlea. We show that 1,563 and 1,616 TF genes are respectively expressed in IHCs and OHCs among 2,230 putative mouse TF genes. While 1,536 are commonly expressed in both populations, 73 genes are differentially expressed (with at least a twofold difference) in IHCs and 13 are differentially expressed in OHCs. Our datasets represent the first cell type-specific TF databases for two populations of sensory receptor cells and are key informational resources for understanding the molecular mechanism underlying the biological properties and phenotypical differences of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.