Evidence map›Paper›PMID 26974304›Full record

ReviewSeminars in respiratory and critical care medicine2016

Obstructive Lung Diseases in HIV: A Clinical Review and Identification of Key Future Research Needs.

M Bradley Drummond, Ken M Kunisaki, Laurence Huang

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Seminars in respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04070248 (Investigating the Association Between Altered Lung MicroBiome and HIV-associated Chronic Obstructive Pulmonary Disease in a Ugandan Cohort), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04070248 unknown statusnot on this mapstarted 2019, after this paper: background citation

Investigating the Association Between Altered Lung MicroBiome and HIV-associated Chronic Obstructive Pulmonary Disease in a Ugandan Cohort

TypeobservationalSponsorMakerere UniversityRan2019 to 2021Enrolled200ConditionsCOPD, HIV/AIDSArmsNo intervention
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Feasibility of a Smartphone-Based Tobacco Treatment for HIV-Infected Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Chronic obstructive pulmonary disease in HIV.Expert review of respiratory medicine · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

M Bradley DrummondDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ken M KunisakiSection of Pulmonary, Critical Care, and Sleep Medicine, Minneapolis VA Health Care System, Minneapolis, Minnesota.
Laurence HuangDivision of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California.
Johns Hopkins Medicine · USSan Francisco General Hospital · USUniversity of Minnesota · US

Funding

The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
INCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERSR01DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 1999 to 2017
$15.5M
Inflammation, Aging, Microbes, Obstructive Lung Disease and Diffusion Abnormalities (I AM OLD-DA) Study - Diversity SupplementR01HL128156 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE, HUNT, PETER W · 2015 to 2024
$7.1M
The Study of HIV Infection in the Etiology of Lung Disease (SHIELD)R01HL090483 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2007 to 2011
$4.4M
Effects of HIV antiretroviral therapy on pulmonary function in a randomized trialR01HL096453 · NHLBI · UNIVERSITY OF MINNESOTA · PI KUNISAKI, KEN M. · 2009 to 2017
$4.2M
International HIV-associated Opportunistic Pneumonias (IHOP) StudyR01HL090335 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2007 to 2011
$4.0M
Lung Microbiome in Cohorts of HIV-Infected Persons (Lung MicroCHIP) StudyU01HL098964 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2009 to 2013
$3.9M
Immune Mechanisms of HIV-associated COPDU01HL121814 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D, MCDYER, JOHN F · 2013 to 2017
$3.5M
Predictors, consequences and mechanisms of accelerated lung aging in HIVR01HL126549 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2014 to 2018
$3.2M
Cathelicidin and Vitamin D: Impact on Populations At-Risk and with COPDR01HL125432 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DRUMMOND, MICHAEL BRADLEY · 2015 to 2019
$3.1M
Patient-Oriented Research and Mentoring in PneumocystisK24HL087713 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2006 to 2018
$1.8M
Patient-Oriented Research and Mentorship in HIV and Non-Communicable DiseasesK24AI118591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2015 to 2019
$766k
NHLBI NIH HHS K24 HL087713NHLBI NIH HHS R01 HL090335NHLBI NIH HHS R01 HL090483NHLBI NIH HHS R01 HL096453NHLBI NIH HHS R01 HL125432NHLBI NIH HHS R01 HL125432-01A1NHLBI NIH HHS R01 HL126549NHLBI NIH HHS R01 HL128156NHLBI NIH HHS U01 HL098964NHLBI NIH HHS U01 HL121814NIAID NIH HHS K24 AI118591NIDA NIH HHS R01 DA012568NIDA NIH HHS U01 DA036297
6 · The paper itself

Abstract

HIV infection has shifted from what was once a disease directly impacting short-term mortality to what is now a chronic illness controllable in the era of effective combination antiretroviral therapy (ART). In this setting, life expectancy for HIV-infected individual is nearly comparable to that of individuals without HIV. Subsequent to this increase in life expectancy, there has been recognition of increased multimorbidity among HIV-infected persons, with prevalence of comorbid chronic illnesses now approaching 65%. Obstructive lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are prevalent conditions associated with substantial morbidity and mortality in the United States. There is overlap in risk factors for HIV acquisition and chronic lung diseases, including lower socioeconomic status and the use of tobacco and illicit drugs. Objectives of this review are to (1) summarize the current state of knowledge regarding COPD and asthma among HIV-infected persons, (2) highlight implications for clinicians caring for patients with these combined comorbidities, and (3) identify key research initiatives to reduce the burden of obstructive lung diseases among HIV-infected persons.

Indexed as

Anti-HIV AgentsAsthmaHIV InfectionsHumansPulmonary Disease, Chronic ObstructiveRisk FactorsSmokingSocioeconomic FactorsSubstance-Related DisordersAnti-HIV Agents

Identifiers

PMID26974304
PMCPMC4809361
OpenAlexW2298819052

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.