Evidence map›Paper›PMID 26974193›Full record

ArticleChemical communications (Cambridge, England)2016

Mitochondria-specific conjugated polymer nanoparticles.

Megan Twomey, Eladio Mendez, Rajesh Kumar Manian, Sunwoo Lee, Joong Ho Moon

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Megan TwomeyDepartment of Chemistry and Biochemistry, Biomolecular Sciences Institute, Florida International University, Miami, Florida 33199, USA. jmoon@fiu.edu.
Eladio Mendez
Rajesh Kumar Manian
Sunwoo Lee
Joong Ho Moon

Funding

MBRS RESEARCH INITIATIVE FOR SCIENTIFIC ENHANCEMENTR25GM061347 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI LICKLITER, ROBERT E · 2000 to 2016
$14.7M
Multiphoton Probes for Biomedical ImagingSC1GM092778 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI MOON, JOONGHO · 2011 to 2014
$829k
NIGMS NIH HHS GM092778NIGMS NIH HHS R25 GM061347NIGMS NIH HHS R25GM61347NIGMS NIH HHS SC1 GM092778
6 · The paper itself

Abstract

Biodegradable conjugated polymer nanoparticles (CPNs) were prepared for high mitochondrial targeting in live cancer cells. The degradable CPNs are nontoxic and specifically localized to the mitochondria of live tumor cells through macropinocytosis followed by intracellular degradation and trafficking.

Indexed as

Microscopy, ConfocalMitochondriaNanoparticlesPinocytosisPolymersPolymers

Identifiers

PMID26974193
PMCPMC4821631

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.