Evidence map›Paper›PMID 26974146›Full record

Trial reportPloS one2016

Effect of Providing Multiple Micronutrients in Powder through Primary Healthcare on Anemia in Young Brazilian Children: A Multicentre Pragmatic Controlled Trial.

Marly A Cardoso, Rosangela A Augusto, Gisele A Bortolini, Cristieli S M Oliveira, Daniela C Tietzman, Leopoldina A S Sequeira, Maria Claret C M Hadler, Maria do Rosario G Peixoto, Pascoal T Muniz, Márcia R Vitolo and 3 more

Erratum issuedOpen access · goldAbstract readClinical TrialMulticenter StudyPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 6 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 6 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  5. Fortification of staple foods with vitamin A for vitamin A deficiency.The Cochrane database of systematic reviews · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Marly A CardosoDepartment of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
Rosangela A AugustoDepartment of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
Gisele A BortoliniCoordenação Geral de Alimentação e Nutrição (CGAN), Ministry of Health, Brasília, Brazil.
Cristieli S M OliveiraDepartment of Health Sciences, Federal University of Acre, Rio Branco, Brazil.
Daniela C TietzmanUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Leopoldina A S SequeiraDepartment of Nutrition, Universidade Federal de Pernambuco, Recife, Brazil.
Maria Claret C M HadlerSchool of Nutrition, Federal University of Goiás, Goiânia, Brazil.
Maria do Rosario G PeixotoSchool of Nutrition, Federal University of Goiás, Goiânia, Brazil.
Pascoal T MunizDepartment of Health Sciences, Federal University of Acre, Rio Branco, Brazil.
Márcia R VitoloUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Pedro I C LiraDepartment of Nutrition, Universidade Federal de Pernambuco, Recife, Brazil.
Patrícia C JaimeDepartment of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
ENFAC Working Group
Universidade de São Paulo · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal de Goiás · BRUniversidade Federal de Pernambuco · BRUniversidade Federal do Acre · BRMinistério da Saúde · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple micronutrients in powder (MNP) are recommended by WHO to prevent anemia in young children. However, evidences for its effectiveness in different populations and improvements in other outcomes (e.g. linear growth and vitamin A deficiency) are scarce.

methodsA multicentre pragmatic controlled trial was carried out in primary health centres. At study baseline, a control group (CG) of children aged 10- to 14 months (n = 521) was recruited in the routine healthcare for assessing anemia, anthropometric and micronutrient status. At the same time, an intervention group (IG) of infants aged 6- to 8 months (n = 462) was recruited to receive MNP daily in complementary feeding over a period of 60 days. Both study groups were compared when the IG infants reached the age of the CG children at enrolment.

resultsIn CG, the prevalence of anemia [hemoglobin (Hb) < 110 g/L], iron deficiency (ID, plasma ferritin < 12 μg/L or TfR > 8.3 mg/L), and vitamin A deficiency (VAD, serum retinol < 0.70μmol/L) were 23.1%, 37.4%, and 17.4%, respectively. Four to six months after enrolment, when the IG participants had the same age of the controls at the time of testing, the prevalence of anemia, ID and VAD in IG were 14.3%, 30.1% and 7.9%, respectively. Adjusting for city, health centre, maternal education, and age, IG children had a lower likelihood of anemia and VAD [Prevalence Ratio (95% CI) = 0.63 (0.45, 0.88) and 0.45 (0.29, 0.69), respectively] when compared with CG children. The adjusted mean distributions of Hb and length-for-age Z-scores improved by 2 SE in the IG compared to CG children.

conclusionsMNP effectively reduced anemia and improved growth and micronutrient status among young Brazilian children.

trial registrationRegistro Brasileiro de Ensaios Clinicos RBR-5ktv6b.

Indexed as

Primary Health CareAnemia, Iron-DeficiencyChild, PreschoolFerritinsHemoglobinsHumansInfantMicronutrientsPrevalenceFerritinsHemoglobinsMicronutrients

Identifiers

PMID26974146
PMCPMC4790963
OpenAlexW2329835675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.