ArticleJCI insight2016
Autoimmune response to transthyretin in juvenile idiopathic arthritis.
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
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- Non-mutational neoantigens in disease.Nature immunology · 2024Review
- Methionine oxidation selectively enhances T cell reactivity against a melanoma antigen.iScience · 2023Article
- The yin/yang balance of the MHC-selfFrontiers in immunology · 2022Review
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- Thymus and autoimmunity.Seminars in immunopathology · 2021Review
- Chd4 choreographs self-antigen expression for central immune tolerance.Nature immunology · 2020Article
- Protein Biomarkers in Uveitis.Frontiers in immunology · 2020Review
- The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity.Diabetes · 2019Article
- Antigen recognition in autoimmune diabetes: a novel pathway underlying disease initiation.Precision clinical medicine · 2018Review
- Involvement of Akt in mitomycin C and its analog triggered cytotoxicity in MCF-7 and K562 cancer cells.Chemical biology & drug design · 2018Article
- A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis.Frontiers in immunology · 2018Review
- Transthyretin deposition promotes progression of osteoarthritis.Aging cell · 2017Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatological condition. Although it has been proposed that JIA has an autoimmune component, the autoantigens are still unknown. Using biochemical and proteomic approaches, we identified the molecular chaperone transthyretin (TTR) as an antigenic target for B and T cell immune responses. TTR was eluted from IgG complexes and affinity purified from 3 JIA patients, and a statistically significant increase in TTR autoantibodies was observed in a group of 43 JIA patients. Three cryptic, HLA-DR1-restricted TTR peptides, which induced CD4
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.