Evidence map›Paper›PMID 26973848›Full record

ArticleClinical microbiology (Los Angeles, Calif.)2015

Proteome Analyses of

Nazrul Islam, Julia M Ross, Mark R Marten

Open access · hybridAbstract read
In one paragraph

Article in Clinical microbiology (Los Angeles, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Unique structural and ligand-binding properties of theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Unique structural and ligand binding properties of thebioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies.Microbiology and molecular biology reviews : MMBR · 2020
    Review
  8. AViruses · 2020
    Article
  9. Virulence Factors Produced byMolecular & cellular proteomics : MCP · 2019
    Article
  10. iTRAQ-Based Quantitative Proteomic Profiling ofFrontiers in microbiology · 2019
    Article
  11. Article
  12. Blood Serum Affects Polysaccharide Production and Surface Protein Expression inAdvances in biotechnology & microbiology (Newbury, Calif.) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nazrul IslamDepartment of Chemical and Biochemical Engineering, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, USA.
Julia M RossDepartment of Chemical and Biochemical Engineering, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, USA.
Mark R MartenDepartment of Chemical and Biochemical Engineering, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, USA.
University of Maryland, Baltimore County · US

Funding

Characterizing the Phenotype of Staphylococcal BiofilmsR01AI059369 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI ROSS, JULIA M · 2005 to 2008
$1.4M
NIAID NIH HHS R01 AI059369
6 · The paper itself

Abstract

Our studies demonstrate that sodium chloride (NaCl) induces changes in biofilm, mediated by increased production of polysaccharides intercellular adhesion (PIA). We identified 12 proteins that showed higher abundance in increased level of NaCl. This includes one important protein (IsaA) known to be associated with biofilm stability. In addition, we also found higher abundance of a cold shock protein, CspA, at higher NaCl. We have also identified several other proteins that are differentially expressed to the elevated levels of NaCl and mapped them in the regulatory pathways of PIA. The majority of proteins are involved with various aspects bacterial metabolic function. Our results demonstrated that NaCl influences gene regulatory networks controlling exopolysaccharide expression.

Indexed as

BiofilmElevatedNaClProteomeStaphylococcus aureus

Identifiers

PMID26973848
PMCPMC4786021
OpenAlexW2098540855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.