ArticleFrontiers in plant science2016
Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome P450 83A1 Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Endogenous RALF peptide function is required for powdery mildew host colonization.The New phytologist · 2026Article
- Powdery mildew induces chloroplast storage lipid formation at the expense of host thylakoids to promote spore production.The Plant cell · 2025Article
- Developing multifunctional crops by engineering Brassicaceae glucosinolate pathways.Plant communications · 2023Review
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- TheFrontiers in plant science · 2022Article
- The Role of thePlants (Basel, Switzerland) · 2021Article
- Characterization of Selected Plant Growth-Promoting Rhizobacteria and Their Non-Host Growth Promotion Effects.Microbiology spectrum · 2021Article
- Transcriptome dynamics underlying elicitor-induced defense responses against Septoria leaf spot disease of tomato (Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- The Versatile Roles of Sulfur-Containing Biomolecules in Plant Defense-A Road to Disease Resistance.Plants (Basel, Switzerland) · 2020Review
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- Plant endophytes promote growth and alleviate salt stress in Arabidopsis thaliana.Scientific reports · 2020Article
- Inactivation of UDP-Glucose Sterol Glucosyltransferases EnhancesFrontiers in plant science · 2019Article
- Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Small secondary metabolites, including glucosinolates and the major phytoalexin camalexin, play important roles in immunity in Arabidopsis thaliana. We isolated an Arabidopsis mutant with increased resistance to the powdery mildew fungus Golovinomyces cichoracearum and identified a mutation in the gene encoding cytochrome P450 83A1 monooxygenase (CYP83A1), which functions in glucosinolate biosynthesis. The cyp83a1-3 mutant exhibited enhanced defense responses to G. cichoracearum and double mutant analysis showed that this enhanced resistance requires NPR1, EDS1, and PAD4, but not SID2 or EDS5. In cyp83a1-3 mutants, the expression of genes related to camalexin synthesis increased upon G. cichoracearum infection. Significantly, the cyp83a1-3 mutant also accumulated higher levels of camalexin. Decreasing camalexin levels by mutation of the camalexin synthetase gene PAD3 or the camalexin synthesis regulator AtWRKY33 compromised the powdery mildew resistance in these mutants. Consistent with these observations, overexpression of PAD3 increased camalexin levels and enhanced resistance to G. cichoracearum. Taken together, our data indicate that accumulation of higher levels of camalexin contributes to increased resistance to powdery mildew.
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