ArticleFrontiers in plant science2016
Reducing Cytoplasmic Polyamine Oxidase Activity in Arabidopsis Increases Salt and Drought Tolerance by Reducing Reactive Oxygen Species Production and Increasing Defense Gene Expression.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 60 citations in OpenAlex.
- Light-defined cold acclimation reprograms organ-specific metabolic and transcriptional landscapes for salt stress responses in maize.Plant cell reports · 2026Article
- Dual functions of thermospermine in plant growth and stress responses.Amino acids · 2026Review
- Evolution and Expression Analysis of PAO Gene Family in Cotton: Focusing on Fiber Development and Stress Response.Plants (Basel, Switzerland) · 2026Article
- Genome-Wide Analysis of Soybean Polyamine Oxidase Genes Reveals Their Roles in Flower Development and Response to Abiotic Stress.Plants (Basel, Switzerland) · 2025Article
- Effect of Temperature on Polyamine Oxidase Genes inInternational journal of molecular sciences · 2025Article
- Molecular Insights into the Synergistic Effects of Putrescine and Ammonium on Dinoflagellates.International journal of molecular sciences · 2024Article
- Subfunctionalization of Parental Polyamine Oxidase (PAO) Genes in the Allopolyploid TobaccoGenes · 2023Article
- L-Aminoguanidine Induces Imbalance of ROS/RNS Homeostasis and Polyamine Catabolism of Tomato Roots after Short-Term Salt Exposure.Antioxidants (Basel, Switzerland) · 2023Article
- Roles of S-Adenosylmethionine and Its Derivatives in Salt Tolerance of Cotton.International journal of molecular sciences · 2023Review
- Response to Cadmium Toxicity: Orchestration of Polyamines and microRNAs in Maize Plant.Plants (Basel, Switzerland) · 2023Article
- Plant Peroxisomal Polyamine Oxidase: A Ubiquitous Enzyme Involved in Abiotic Stress Tolerance.Plants (Basel, Switzerland) · 2023Review
- GUS Reporter-Aided Promoter Deletion Analysis ofInternational journal of molecular sciences · 2023Article
- Polyamine Oxidase-Generated Reactive Oxygen Species in Plant Development and Adaptation: The Polyamine Oxidase-NADPH Oxidase Nexus.Antioxidants (Basel, Switzerland) · 2022Review
- Genome-Wide Identification of Polyamine Oxidase (PAO) Family Genes: Roles ofInternational journal of molecular sciences · 2022Article
- Genome-Wide Analysis of theInternational journal of molecular sciences · 2022Article
- Transcriptomic Insights on the Preventive Action of Apple (cv Granny Smith) Skin Wounding on Superficial Scald Development.International journal of molecular sciences · 2021Article
- RIC7 plays a negative role in ABA-induced stomatal closure by inhibiting HPlant signaling & behavior · 2021Article
- Morphological, Physiological and Molecular Markers for Salt-Stressed Plants.Plants (Basel, Switzerland) · 2021Review
- Biologia futura: the role of polyamine in plant science.Biologia futura · 2020Review
- Phenotyping in Arabidopsis and Crops-Are We Addressing the Same Traits? A Case Study in Tomato.Genes · 2020Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The link between polyamine oxidases (PAOs), which function in polyamine catabolism, and stress responses remains elusive. Here, we address this issue using Arabidopsis pao mutants in which the expression of the five PAO genes is knocked-out or knocked-down. As the five single pao mutants and wild type (WT) showed similar response to salt stress, we tried to generate the mutants that have either the cytoplasmic PAO pathway (pao1 pao5) or the peroxisomal PAO pathway (pao2 pao3 pao4) silenced. However, the latter triple mutant was not obtained. Thus, in this study, we used two double mutants, pao1 pao5 and pao2 pao4. Of interest, pao1 pao5 mutant was NaCl- and drought-tolerant, whereas pao2 pao4 showed similar sensitivity to those stresses as WT. To reveal the underlying mechanism of salt tolerance, further analyses were performed. Na uptake of the mutant (pao1 pao5) decreased to 75% of WT. PAO activity of the mutant was reduced to 62% of WT. The content of reactive oxygen species (ROS) such as hydrogen peroxide, a reaction product of PAO action, and superoxide anion in the mutant became 81 and 72% of the levels in WT upon salt treatment. The mutant contained 2.8-fold higher thermospermine compared to WT. Moreover, the mutant induced the genes of salt overly sensitive-, abscisic acid (ABA)-dependent- and ABA-independent- pathways more strongly than WT upon salt treatment. The results suggest that the Arabidopsis plant silencing cytoplasmic PAOs shows salinity tolerance by reducing ROS production and strongly inducing subsets of stress-responsive genes under stress conditions.
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