ArticleFrontiers in microbiology2016
Global MLST of Salmonella Typhi Revisited in Post-genomic Era: Genetic Conservation, Population Structure, and Comparative Genomics of Rare Sequence Types.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 34 citations in OpenAlex.
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- Whole-genome sequencing of multidrug resistanceFrontiers in public health · 2023Article
- Molecular Epidemiology of Sporadic and Outbreak-RelatedInfectious disease reports · 2022Article
- Molecular characterization of circulating Salmonella Typhi strains in an urban informal settlement in Kenya.PLoS neglected tropical diseases · 2022Article
- Antimicrobial susceptibility and genomic profiling ofIJID regions · 2022Article
- Virulence Gene Profile, Antimicrobial Resistance and Multilocus Sequence Typing ofAnimals : an open access journal from MDPI · 2022Article
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- Multilevel genome typing: genomics-guided scalable resolution typing of microbial pathogens.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Ciprofloxacin-ResistantMicroorganisms · 2020Article
- Characterization of pTS14, an IncF2:A1:B1 Plasmid CarryingFrontiers in microbiology · 2020Article
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- Genome Sequence of "Anthococcus," a Novel Genus of the Family Streptococcaceae Isolated from Flowers.Genome announcements · 2016Article
- Identification and Characterization of a GeneFrontiers in cellular and infection microbiology · 2016Article
- Comparative genomics analyses revealed two virulentGut pathogens · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Typhoid fever, caused by Salmonella enterica serovar Typhi, remains an important public health burden in Southeast Asia and other endemic countries. Various genotyping methods have been applied to study the genetic variations of this human-restricted pathogen. Multilocus sequence typing (MLST) is one of the widely accepted methods, and recently, there is a growing interest in the re-application of MLST in the post-genomic era. In this study, we provide the global MLST distribution of S. Typhi utilizing both publicly available 1,826 S. Typhi genome sequences in addition to performing conventional MLST on S. Typhi strains isolated from various endemic regions spanning over a century. Our global MLST analysis confirms the predominance of two sequence types (ST1 and ST2) co-existing in the endemic regions. Interestingly, S. Typhi strains with ST8 are currently confined within the African continent. Comparative genomic analyses of ST8 and other rare STs with genomes of ST1/ST2 revealed unique mutations in important virulence genes such as flhB, sipC, and tviD that may explain the variations that differentiate between seemingly successful (widespread) and unsuccessful (poor dissemination) S. Typhi populations. Large scale whole-genome phylogeny demonstrated evidence of phylogeographical structuring and showed that ST8 may have diverged from the earlier ancestral population of ST1 and ST2, which later lost some of its fitness advantages, leading to poor worldwide dissemination. In response to the unprecedented increase in genomic data, this study demonstrates and highlights the utility of large-scale genome-based MLST as a quick and effective approach to narrow the scope of in-depth comparative genomic analysis and consequently provide new insights into the fine scale of pathogen evolution and population structure.
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