ArticleFrontiers in microbiology2016
Impact of Timing and Dosage of a Fluoroquinolone Treatment on the Microbiological, Pathological, and Clinical Outcomes of Calves Challenged with Mannheimia haemolytica.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Predicted PK/PD inadequacy of amoxicillin delivered in drinking water against respiratory pathogens in post-weaning piglets: can time-restricted dosing improve animals' exposure and potential treatment efficacy?Veterinary and animal science · 2026Article
- The calf holobiont under challenge: longitudinal microbiota-pathogen dynamics and respiratory health.Veterinary research · 2026Article
- Decoding the dynamics of calves' respiratory and gut microbiota: exploring stability, resistance, and individual patterns.Animal microbiome · 2025Article
- Protection against Bovine Respiratory Syncytial Virus Afforded by Maternal Antibodies from Cows Immunized with an Inactivated Vaccine.Vaccines · 2023Article
- Influence of Single Dose Enrofloxacin Injection on Development of Fluoroquinolone Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Understanding the mechanisms of viral and bacterial coinfections in bovine respiratory disease: a comprehensive literature review of experimental evidence.Veterinary research · 2022Review
- Effect of Danofloxacin Treatment on the Development of Fluoroquinolone Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Bovine Animal Model for Studying the Maternal Microbiome,Frontiers in microbiology · 2022Review
- Toward the automated detection of behavioral changes associated with the post-weaning transition in pigs.Frontiers in veterinary science · 2022Article
- Antimicrobial Resistance Situation in Indonesia: A Challenge of Multisector and Global Coordination.Journal of tropical medicine · 2022Article
- Enhanced Pathogenesis Caused by Influenza D Virus and Mycoplasma bovis Coinfection in Calves: a Disease Severity Linked with Overexpression of IFN-γ as a Key Player of the Enhanced Innate Immune Response in Lungs.Microbiology spectrum · 2021Article
- Comparison of antimicrobial prescription patterns in calves in Switzerland before and after the launch of online guidelines for prudent antimicrobial use.BMC veterinary research · 2021Article
- The Effects of Ursolic Acid Treatment on Immunopathogenesis FollowingFrontiers in veterinary science · 2021Article
- Levers to Improve Antibiotic Treatment of Lambs via Drinking Water in Sheep Fattening Houses: The Example of the Sulfadimethoxine/Trimethoprim Combination.Antibiotics (Basel, Switzerland) · 2020Article
- Intranasal Bacterial Therapeutics Reduce Colonization by the Respiratory Pathogen Mannheimia haemolytica in Dairy Calves.mSystems · 2020Article
- Pathogenesis of co-infections of influenza D virus and Mannheimia haemolytica in cattle.Veterinary microbiology · 2019Article
- Pathogenesis, Host Innate Immune Response, and Aerosol Transmission of Influenza D Virus in Cattle.Journal of virology · 2019Article
- Variation in fluoroquinolone pharmacodynamic parameter values among isolates of two bacterial pathogens of bovine respiratory disease.Scientific reports · 2018Article
- Optimization of Antimicrobial Treatment to Minimize Resistance Selection.Microbiology spectrum · 2018Review
- Implementing Precision Antimicrobial Therapy for the Treatment of Bovine Respiratory Disease: Current Limitations and Perspectives.Frontiers in veterinary science · 2017Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficacy of an early and low inoculum-adjusted marbofloxacin treatment was evaluated on microbiological and clinical outcomes in calves infected with 4.10(7) CFU of Mannheimia haemolytica A1. Twenty-two calves were included based on their rectal temperature rise in the 10 h after challenge and allocated in four groups, receiving a single intramuscular injection of saline (CON), 2 mg/kg marbofloxacin 2-4 h after inclusion (early treatment, E2), 2 or 10 mg/kg marbofloxacin 35-39 h after inclusion (late treatments, L2, L10). In CON calves, M. haemolytica DNA loads in bronchoalveolar lavages continuously increased from inclusion to day 4, and were associated with persistent respiratory clinical signs and lung lesions. At times of early and late treatments, M. haemolytica loads ranged within 3.5-4 and 5.5-6 log10 DNA copies/mL, respectively. Early 2 mg/kg marbofloxacin treatment led to rapid and total elimination of bacteria in all calves. The late treatments induced a reduction of bacterial loads, but 3 of 6 L2 and 1 of 6 L10 calves were still positive for M. haemolytica at day 4. Except for CON calves, all animals exhibited clinical improvement within 24 h after treatment. However, early 2 mg/kg treatment was more efficacious to prevent pulmonary lesions, as indicated by the reduction of the extension and severity of gross lesions and by the histopathological scores. These results demonstrated for the first time that a reduced antibiotic regimen given at an early stage of the disease and targeting a low bacterial load could be efficacious in a natural bovine model of pneumonia.
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