ArticleFrontiers in physiology2016
Entropy Production and the Pressure-Volume Curve of the Lung.
Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Injury Mechanics in Surfactant-Depleted and Healthy Rat Lungs: A Multi-scale Consideration of Artificial and Physiological Ventilation.Annals of biomedical engineering · 2026Article
- Human ex-vivo lung mechanics differ under positive- and negative-pressure ventilation.Respiratory research · 2026Article
- Fibrotic and emphysematous murine lung mechanics under negative-pressure ventilation.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Positive- and Negative-Pressure Ventilation Characterized by Local and Global Pulmonary Mechanics.American journal of respiratory and critical care medicine · 2023Article
- Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure-volume curves.Scientific reports · 2022Article
- Mouse lung mechanical properties under varying inflation volumes and cycling frequencies.Scientific reports · 2022Article
- Perspectives on Complexity, Chaos and Thermodynamics in Environmental Pathology.International journal of environmental research and public health · 2021Article
- Theoretical open-loop model of respiratory mechanics in the extremely preterm infant.PloS one · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We investigate analytically the production of entropy during a breathing cycle in healthy and diseased lungs. First, we calculate entropy production in healthy lungs by applying the laws of thermodynamics to the well-known transpulmonary pressure-volume (P-V) curves of the lung under the assumption that lung tissue behaves as an entropic spring similar to rubber. The bulk modulus, B, of the lung is also derived from these calculations. Second, we extend this approach to elastic recoil disorders of the lung such as occur in pulmonary fibrosis and emphysema. These diseases are characterized by particular alterations in the P-V relationship. For example, in fibrotic lungs B increases monotonically with disease progression, while in emphysema the opposite occurs. These diseases can thus be mimicked simply by making appropriate adjustments to the parameters of the P-V curve. Using Clausius's formalism, we show that entropy production, ΔS, is related to the hysteresis area, ΔA, enclosed by the P-V curve during a breathing cycle, namely, ΔS=ΔA∕T, where T is the body temperature. Although ΔA is highly dependent on the disease, such formula applies to healthy as well as diseased lungs, regardless of the disease stage. Finally, we use an ansatz to predict analytically the entropy produced by the fibrotic and emphysematous lungs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.