ReviewFrontiers in physiology2016
Epidemiology, Etiology, and Treatment of Isolated Cleft Palate.
Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 5 syntheses or guidelines pooled it, 215 citations in OpenAlex.
- Maternal factors increase risk of orofacial cleft: a meta-analysis.Scientific reports · 2024Pooled it
- Perioperative pain management for cleft palate surgery: a systematic review and procedure-specific postoperative pain management (PROSPECT) recommendations.Regional anesthesia and pain medicine · 2024Pooled it
- Survival, hospitalisation and surgery in children born with Pierre Robin sequence: a European population-based cohort study.Archives of disease in childhood · 2023Pooled it
- Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study.International journal of epidemiology · 2020Pooled it
- Diagnostic accuracy of fetal MRI to detect cleft palate: a meta-analysis.European journal of pediatrics · 2020Pooled it
- The Outcomes of Modified Millard Technique Versus Tennison-Randall Technique in Unilateral Cleft Lip Repair: A Comparative Trial.African journal of paediatric surgery : AJPS · 2024Trial
- Timing of Primary Surgery for Cleft Palate.The New England journal of medicine · 2023Trial
- Growth in Children with a Cleft Lip and/or Palate in 8 US Hospitals: A Retrospective Cohort Study.JDR clinical and translational research · 2026Article
- Feasibility of Imaging the Uvula at the Midtrimester Anomaly Ultrasound: A Retrospective Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- A Novel Nonsense Variant in TBX15 Transcription Factor Suggests an Expanded Genetic Spectrum Of Submucous Cleft Palate.International dental journal · 2026Article
- Acetylation-triggered degradation of MSX1 impairs palatal development.Cell death discovery · 2026Article
- The "Dynamic Tongue Contraction Technique" for Diagnosis of Soft Palate Cleft in Cases of Cleft Lip and Palate Sequence.Prenatal diagnosis · 2026Article
- Toward Understanding the Role of miRNAs in Cleft Palate Only: Observations from Patient Tissues and In Vitro Assays.International journal of molecular sciences · 2026Article
- Virtual Surgical Planning (VSP) in Orthognathic Surgery for Non-Syndromic Cleft Patients: A Scoping Review of Trends and Clinical Outcomes.Journal of clinical medicine · 2026Review
- A Lingual Ultrasound Study of Speech in Patients With Cleft Lip and Palate Following Orthognathic Surgery.Orthodontics & craniofacial research · 2025Article
- Surgical Repair of Cleft Lip: Comparison of Neonatal and Standard Timing in a Systematic Review.Cureus · 2025Review
- Risk Factors for Nonsyndromic Orofacial Clefts Among Saudi Children.Clinical and experimental dental research · 2025Article
- Epidemiologic trends of cleft lip and/or palate in Switzerland.BMC oral health · 2025Article
- Caries status among 6-year-old children born with cleft lip and palate in Norway: a nationwide study.Frontiers in oral health · 2025Article
- Assessment of level of knowledge and satisfaction of website about cleft lip and palate.CoDAS · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Isolated cleft palate (CPO) is the rarest form of oral clefting. The incidence of CPO varies substantially by geography from 1.3 to 25.3 per 10,000 live births, with the highest rates in British Columbia, Canada and the lowest rates in Nigeria, Africa. Stratified by ethnicity/race, the highest rates of CPO are observed in non-Hispanic Whites and the lowest in Africans; nevertheless, rates of CPO are consistently higher in females compared to males. Approximately fifty percent of cases born with cleft palate occur as part of a known genetic syndrome or with another malformation (e.g., congenital heart defects) and the other half occur as solitary defects, referred to often as non-syndromic clefts. The etiology of CPO is multifactorial involving genetic and environmental risk factors. Several animal models have yielded insight into the molecular pathways responsible for proper closure of the palate, including the BMP, TGF-β, and SHH signaling pathways. In terms of environmental exposures, only maternal tobacco smoke has been found to be strongly associated with CPO. Some studies have suggested that maternal glucocorticoid exposure may also be important. Clearly, there is a need for larger epidemiologic studies to further investigate both genetic and environmental risk factors and gene-environment interactions. In terms of treatment, there is a need for long-term comprehensive care including surgical, dental and speech pathology. Overall, five main themes emerge as critical in advancing research: (1) monitoring of the occurrence of CPO (capacity building); (2) detailed phenotyping of the severity (biology); (3) understanding of the genetic and environmental risk factors (primary prevention); (4) access to early detection and multidisciplinary treatment (clinical services); and (5) understanding predictors of recurrence and possible interventions among families with a child with CPO (secondary prevention).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.