ReviewFrontiers in neuroscience2016
The Contradictory Effects of Neuronal Hyperexcitation on Adult Hippocampal Neurogenesis.
Review in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Pathophysiological roles of neural stem cells in neuropsychiatric diseases: from plasticity to pharmacological targeting.Acta pharmacologica Sinica · 2026Review
- The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.Immunity · 2025Article
- HB-EGF activates EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures.Life science alliance · 2024Article
- Strategic pathway analysis for dual management of epilepsy and comorbid depression: a systems biology perspective.In silico pharmacology · 2024Article
- Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose-response study.Biology of sex differences · 2023Article
- Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?International journal of molecular sciences · 2023Review
- Editorial: Global excellence in neurogenesis: Europe.Frontiers in neuroscience · 2023Article
- Electroconvulsive seizures regulate various stages of hippocampal cell genesis and mBDNF at different times after treatment in adolescent and adult rats of both sexes.Frontiers in molecular neuroscience · 2023Article
- Spinal Cord Injury Leads to Hippocampal Glial Alterations and Neural Stem Cell Inactivation.Cellular and molecular neurobiology · 2022Article
- Functional Activation of Newborn Neurons Following Alcohol-Induced Reactive Neurogenesis.Brain sciences · 2021Article
- Stem cell quiescence: the challenging path to activation.Development (Cambridge, England) · 2021Review
- Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Retinoic Acid Is Required for Neural Stem and Progenitor Cell Proliferation in the Adult Hippocampus.Stem cell reports · 2018Article
- Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice.Oncotarget · 2018Article
- Imaging pathological activities of human brain tissue in organotypic culture.Journal of neuroscience methods · 2018Article
- Specific Features of SVZ Neurogenesis After Cortical Ischemia: a Longitudinal Study.Scientific reports · 2017Article
- Neuronal replacement therapy: previous achievements and challenges ahead.NPJ Regenerative medicine · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult hippocampal neurogenesis is a highly plastic process that responds swiftly to neuronal activity. Adult hippocampal neurogenesis can be regulated at the level of neural stem cell recruitment and activation, progenitor proliferation, as well as newborn cell survival and differentiation. An "excitation-neurogenesis" rule was proposed after the demonstration of the capability of cultured neural stem and progenitor cells to intrinsically sense neuronal excitatory activity. In vivo, this property has remained elusive although recently the direct response of neural stem cells to GABA in the hippocampus via GABAA receptors has evidenced a mechanism for a direct talk between neurons and neural stem cells. As it is pro-neurogenic, the effect of excitatory neuronal activity has been generally considered beneficial. But what happens in situations of neuronal hyperactivity in which neurogenesis can be dramatically boosted? In animal models, electroconvulsive shock markedly increases neurogenesis. On the contrary, in epilepsy rodent models, seizures induce the generation of misplaced neurons with abnormal morphological and electrophysiological properties, namely aberrant neurogenesis. We will herein discuss what is known about the mechanisms of influence of neurons on neural stem cells, as well as the severe effects of neuronal hyperexcitation on hippocampal neurogenesis.
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