ArticleWorld journal of gastroenterology2016
Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population.
Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis.International journal of colorectal disease · 2023Pooled it
- Early-Age Onset Colorectal Neoplasia in Average-Risk Individuals Undergoing Screening Colonoscopy: A Systematic Review and Meta-Analysis.Gastroenterology · 2021Pooled it
- Systematic Review of Prevalence, Risk Factors, and Risk for Metachronous Advanced Neoplasia in Patients With Young-Onset Colorectal Adenoma.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Pooled it
- Risk Factors Associated With Young-Onset Colorectal Adenomas and Cancer: A Systematic Review and Meta-Analysis of Observational Research.Cancer control : journal of the Moffitt Cancer CenterPooled it
- A prospective investigation of early-onset colorectal cancer risk factors-pooled analysis of three large-scale European cohorts.British journal of cancer · 2026Article
- Clinicopathological Features of Endoscopically Resected Early-Onset Colorectal Neoplasia Compared with Later-Onset Cases.Cancers · 2026Article
- Microbiota disparities in stool, oral swabs, and saliva between control and early-onset colorectal neoplasia groups: an exploratory analysis.Frontiers in microbiomes · 2026Article
- Survival Tree Analysis of Interactions Among Factors Associated With Colorectal Cancer Risk in Patients With Type 2 Diabetes: Retrospective Cohort Study.JMIR public health and surveillance · 2025Article
- A Score to Predict Advanced Colorectal Neoplasia in Adults Younger than Age 45.Digestive diseases and sciences · 2025Article
- Brief Report: Trends in Incidence, Mortality, and Disability-Adjusted Life Years for Early-Onset Colorectal Cancer in Canada Between 1990 and 2019.Current oncology (Toronto, Ont.) · 2024Article
- A Perspective Review on Diet Quality, Excess Adiposity, and Chronic Psychosocial Stress and Implications for Early-Onset Colorectal Cancer.The Journal of nutrition · 2024Review
- Birth Cohort Colorectal Cancer (CRC): Implications for Research and Practice.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Review
- Is early-onset cancer an emerging global epidemic? Current evidence and future implications.Nature reviews. Clinical oncology · 2022Review
- Factors associated with the risk of colorectal neoplasia in young adults under age 40.The Korean journal of internal medicine · 2022Article
- Early-Age-Onset Colorectal Cancer in Canada: Evidence, Issues and Calls to Action.Current oncology (Toronto, Ont.) · 2022Article
- Review
- Risk factors for early-onset colorectal cancer: a population-based case-control study in Ontario, Canada.Cancer causes & control : CCC · 2021Article
- Risk Factors for Early-Onset Colorectal Cancer.Gastroenterology · 2020Article
- A Review of the Management of Sporadic Colorectal Adenomas in Young People: Is Surveillance Wasted on the Young?Digestive diseases and sciences · 2019Review
- Age-related rates of colorectal cancer and the factors associated with overall survival.Journal of gastrointestinal oncology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate prevalence and risk factors for colorectal neoplasms in adults aged < 50 years, for whom screening is not recommended.
methodsThis cross-sectional study compared prevalence and characteristics of colorectal and advanced adenomas in patients aged < 50 years who underwent colonoscopy screening with subjects aged ≥ 50 years. To evaluate risk factors for colorectal and advanced adenoma in young adults, we used multivariable logistic regression models. Colorectal neoplasm characteristics were evaluated and compared with those in older patients.
resultsAmong 2819 patients included, prevalences of colorectal adenoma and advanced adenoma were 19.7% and 1.5%, respectively. As patient age increased, so did the prevalence of colorectal neoplasm. However, prevalence of advanced adenoma did not differ between age-groups 45-49 years and ≥ 50 years (OR = 0.43, 95%CI: 0.17-1.07, P = 0.070). In younger age-group (< 50 years), colorectal adenoma was significantly associated with older age, waist circumference (OR = 1.72, 95%CI: 1.15-2.55, P = 0.008), and current smoking (OR = 1.60, 95%CI: 1.07-2.41, P = 0.023). Alcohol consumption was an independent risk factor for colorectal advanced adenoma (OR = 3.69, 95%CI: 1.08-12.54, P = 0.037). Multiple neoplasms and large neoplasms (≥ 1 cm) were more prevalent in subjects ≥ 50 years.
conclusionCurrent screening strategies for colorectal cancer may need to be amended to account for patient age, especially in young subjects with abdominal obesity, current smoking and alcohol consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.