Evidence map›Paper›PMID 26973384›Full record

ReviewWorld journal of gastroenterology2016

Gastric cancer: Current status of lymph node dissection.

Maurizio Degiuli, Giovanni De Manzoni, Alberto Di Leo, Domenico D'Ugo, Erica Galasso, Daniele Marrelli, Roberto Petrioli, Karol Polom, Franco Roviello, Francesco Santullo and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. The significance of small lymph nodes on CT for advanced poorly cohesive gastric carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maurizio DegiuliMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Giovanni De ManzoniMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Alberto Di LeoMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Domenico D'UgoMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Erica GalassoMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Daniele MarrelliMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Roberto PetrioliMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Karol PolomMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Franco RovielloMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Francesco SantulloMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.
Mario MorinoMaurizio Degiuli, Erica Galasso, Mario Morino, Department of Surgery, University of Turin, Citta della Salute e della Scienza, 10126 Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

D2 procedure has been accepted in Far East as the standard treatment for both early (EGC) and advanced gastric cancer (AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials (RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council (MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recurrence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC.

Indexed as

GastroscopyEarly Detection of CancerGastrectomyHumansLaparoscopyLymphatic MetastasisLymph Node ExcisionLymph NodesNeoplasm StagingPancreatectomyRisk FactorsRobotic Surgical ProceduresSplenectomyStomach NeoplasmsSurvival AnalysisTreatment OutcomeD1 gastrectomyD1 plus gastrectomyD2 gastrectomyGastric cancerLaparoscopic lymphadenectomyLymphadenectomyLymph node dissectionRobot assisted lymphadenectomy

Identifiers

PMID26973384
PMCPMC4779911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.