SynthesisOsteoarthritis and cartilage2016
Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies.
Synthesis in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04443452 (Molecular Pathways Involved in Knee Pain), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Pathways Involved in Knee Pain: an Observational Study
Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Trial
- The Role of Ultrasound Versus Radiography in Knee Osteoarthritis: A Bilateral Comparative Study.Life (Basel, Switzerland) · 2026Article
- Frequency and mutual associations of knee osteoarthritis features on ultrasound imaging in recent-onset symptomatic knee osteoarthritis patients: A cross-sectional analysis in a convenience sample of Dutch patients.Osteoarthritis and cartilage open · 2026Article
- The frequency and severity of ultrasound-detected osteoarthritis features in the knees and their associations with pain: Cross-sectional analyses of the Nor-Hand study.Osteoarthritis and cartilage open · 2025Article
- Development of a macrophage polarization-modulating therapeutic agent for osteoarthritis treatment.Journal of orthopaedic surgery and research · 2025Review
- Clinical examination, ultrasound assessment and aspiration of knee effusion in primary knee osteoarthritis patients.Journal of orthopaedic surgery and research · 2023Article
- Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success.Cellular & molecular immunology · 2023Review
- Does weight-bearing versus non-weight-bearing pain reflect different pain mechanisms in knee osteoarthritis?: the Multicenter Osteoarthritis Study (MOST).Osteoarthritis and cartilage · 2022Article
- Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population-the Xiangya Osteoarthritis Study.Arthritis research & therapy · 2021Article
- Pro-regenerative Dialogue Between Macrophages and Mesenchymal Stem/Stromal Cells in Osteoarthritis.Frontiers in cell and developmental biology · 2021Review
- Emerging pharmaceutical therapies for osteoarthritis.Nature reviews. Rheumatology · 2020Review
- Turning the Page in Osteoarthritis Assessment with the Use of Ultrasound.Current rheumatology reports · 2020Review
- Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis.Reumatologia · 2020Review
- Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression.International journal of biological sciences · 2020Article
- Article
- Cartilage Wear Particles Induce an Inflammatory Response Similar to Cytokines in Human Fibroblast-Like Synoviocytes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Thresholds of ultrasound synovial abnormalities for knee osteoarthritis - a cross sectional study in the general population.Osteoarthritis and cartilage · 2019Article
- Basic calcium phosphate and pyrophosphate crystals in early and late osteoarthritis: relationship with clinical indices and inflammation.Clinical rheumatology · 2018Article
- Calcium-Containing Crystals and Osteoarthritis: an Unhealthy Alliance.Current rheumatology reports · 2018Review
- Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data.Arthritis research & therapy · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo examine the prevalence of synovial effusion, synovial hypertrophy and positive Doppler signal (DS) detected by ultrasound (US) in people with knee osteoarthritis (OA) and/or knee pain compared to that in the general population.
methodA systematic literature search was undertaken in Medline, EMBASE, Allied and Complementary Medicine, PubMed Web of Science, and SCOPUS databases in May 2015. Frequencies of US abnormalities in people with knee OA/pain, in the general population or asymptomatic controls were pooled using the random effects model. Publication bias and heterogeneity between studies were examined.
resultsTwenty four studies in people with knee pain/OA and five studies of the general population or asymptomatic controls met the inclusion criteria. The pooled prevalence of US effusion, synovial hypertrophy and positive DS in people with knee OA/pain were 51.5% (95% CI 40.2 to 62.8), 41.5% (26.3-57.5) and 32.7% (8.34-63.24), respectively, which were higher than those in the general population or asymptomatic controls (19.9% (95%CI 7.8-35.3%), 14.5% (0-58.81), and 15.8 (3.08-35.36), respectively). People with knee OA (ACR criteria or radiographic OA) had greater prevalence of US abnormalities than people with knee pain (P = 0.037, P = 0.010 and P = 0.009, respectively).
conclusionsUS detected effusion, synovial hypertrophy and DS are more common in people with knee OA/pain, compared to the general population. These abnormalities relate more to presence of OA structural changes than to pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.