ArticleAllergy2016
Association of season of birth with DNA methylation and allergic disease.
Article in Allergy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation.Epigenetics · 2024Pooled it
- Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude.Clinical epigenetics · 2023Pooled it
- Epigenome-Wide Association of Infant Feeding and Changes in DNA Methylation from Birth to 10 Years.Nutrients · 2020Trial
- Seasonal influences on DNA methylation at birth or at sampling time and their interaction with psychosis risk.Environmental epigenetics · 2026Article
- The Association of Childhood Allergic Diseases with Prenatal Exposure to Pollen Grains Through At-Birth DNA Methylation.Epigenomes · 2025Article
- Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures.Scientific reports · 2024Article
- Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy.Cell & bioscience · 2024Review
- Being born in autumn or winter is associated with asthma and allergic rhinitis in Finland.Clinical and translational allergy · 2024Article
- An epidemiological study of season of birth, mental health, and neuroimaging in the UK Biobank.PloS one · 2024Article
- Being overweight and born in the spring are associated with an increased risk for rhinitis.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Seasonal differences in breastfeeding in the United States: a secondary analysis of longitudinal survey data.International breastfeeding journal · 2022Article
- Review
- Associations among phthalate exposure, DNA methylation of TSLP, and childhood allergy.Clinical epigenetics · 2021Article
- Drivers of Infectious Disease Seasonality: Potential Implications for COVID-19.Journal of biological rhythms · 2021Review
- DNA Methylation at Birth is Associated with Childhood Serum Immunoglobulin E Levels.Epigenetics insights · 2021Article
- Multigenerational Epigenetic Regulation of Allergic Diseases: Utilizing an Experimental Dust Mite-Induced Asthma Model.Frontiers in genetics · 2021Article
- Prenatal famine exposure and adult health outcomes: an epigenetic link.Environmental epigenetics · 2021Review
- Infant Iodine and Selenium Status in Relation to Maternal Status and Diet During Pregnancy and Lactation.Frontiers in nutrition · 2021Article
- Season of birth influences on breastfeeding incidence and duration.World journal of pediatrics : WJP · 2020Article
- Maternal exposure to cold spells during pregnancy is associated with higher blood pressure and hypertension in offspring later in life.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundSeason of birth influences allergy risk; however, the biological mechanisms underlying this observation are unclear. The environment affects DNA methylation, with potentially long-lasting effects on gene expression and disease. This study examined whether DNA methylation could underlie the association between season of birth and allergy.
methodsIn a subset of 18-year-old participants from the Isle of Wight (IoW) birth cohort (n = 367), the risks of birth season on allergic outcomes were estimated. Whole blood epigenome-wide DNA methylation was measured, and season-associated CpGs detected using a training-and-testing-based technique. Validation method examined the 8-year-old Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. The relationships between DNA methylation, season of birth and allergy were examined. CpGs were analysed in IoW third-generation cohort newborns.
resultsAutumn birth increased risk of eczema, relative to spring birth. Methylation at 92 CpGs showed association with season of birth in the epigenome-wide association study. In validation, significantly more CpGs had the same directionality than expected by chance, and four were statistically significant. Season-associated methylation was enriched among networks relating to development, the cell cycle and apoptosis. Twenty CpGs were nominally associated with allergic outcomes. Two CpGs were marginally on the causal pathway to allergy. Season-associated methylation was largely absent in newborns, suggesting it arises post-natally.
conclusionsThis study demonstrates that DNA methylation in adulthood is associated with season of birth, supporting the hypothesis that DNA methylation could mechanistically underlie the effect of season of birth on allergy, although other mechanisms are also likely to be involved.
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Registered trials
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