ArticleNeurobiology of aging2016
β-amyloid, hippocampal atrophy and their relation to longitudinal brain change in cognitively normal individuals.
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Domain-specific changes in everyday cognition: Associations with diagnosis change and gray matter volume change.Neuropsychology · 2026Article
- Morphometry of medial temporal lobe subregions using high-resolution T2-weighted MRI in ADNI3: Why, how, and what's next?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Hippocampal subfield associations with memory depend on stimulus modality and retrieval mode.Brain communications · 2023Article
- Voting Ensemble Approach for Enhancing Alzheimer's Disease Classification.Sensors (Basel, Switzerland) · 2022Article
- Regional age-related atrophy after screening for preclinical alzheimer disease.Neurobiology of aging · 2022Article
- Exploring common genetic contributors to neuroprotection from amyloid pathology.Brain communications · 2022Article
- Can hippocampal subfield measures supply information that could be used to improve the diagnosis of Alzheimer's disease?PloS one · 2022Article
- The latent factor structure underlying regional brain volume change and its relation to cognitive change in older adults.Neuropsychology · 2021Article
- A robust brain signature region approach for episodic memory performance in older adults.Brain : a journal of neurology · 2021Article
- Comparison of Education and Episodic Memory as Modifiers of Brain Atrophy Effects on Cognitive Decline: Implications for Measuring Cognitive Reserve.Journal of the International Neuropsychological Society : JINS · 2021Article
- Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis.Neurobiology of aging · 2019Article
- Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.Neurobiology of aging · 2019Article
- 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice.Communications biology · 2019Article
- Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers.Brain : a journal of neurology · 2018Article
- Education amplifies brain atrophy effect on cognitive decline: implications for cognitive reserve.Neurobiology of aging · 2018Article
- Ethnoracial differences in brain structure change and cognitive change.Neuropsychology · 2018Article
- Brain MRI analysis for Alzheimer's disease diagnosis using an ensemble system of deep convolutional neural networks.Brain informatics · 2018Article
- Brain volume change and cognitive trajectories in aging.Neuropsychology · 2018Article
- Staging of amyloid β, t-tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017 · on this mapArticle
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Authors and funding
7 authors.
Funding
Abstract
Recent literature has examined baseline hippocampal volume and extent of brain amyloidosis to test potential synergistic effects on worsening cognition and extent of brain atrophy. Use of hippocampal volume in prior studies was based on the notion that limbic circuit degeneration is an early manifestation of the Alzheimer's Disease (AD) pathophysiology. To clarify these interactions early in the AD process, we tested the effects of amyloid and baseline normalized hippocampal volume on longitudinal brain atrophy rates in a group of cognitively normal individuals. Results showed that the combination of elevated β-amyloid and baseline hippocampal atrophy is associated with increased rates specific to the limbic circuit and splenium. Importantly, this atrophy pattern emerged from a voxelwise analysis, corroborated by regression models over region of interests in native space. The results are broadly consistent with previous studies of the effects of amyloid and baseline hippocampal atrophy in normals, while pointing to accelerated atrophy of AD-vulnerable regions detectable at the preclinical stage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.