ArticleNeurobiology of aging2016
The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.
Open access · bronzeAbstract read
In one paragraph
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
9.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years.Molecular psychiatry · 2021Pooled it
- From Polygenic Scores to Precision Medicine in Alzheimer's Disease: A Systematic Review.Journal of Alzheimer's disease : JAD · 2020Pooled it
- The genetic risk of Alzheimer's disease beyond APOE ε4: systematic review of Alzheimer's genetic risk scores.Translational psychiatry · 2018Pooled it
- Associations of Hysterectomy and Oophorectomy with Dementia Risk: A Systematic Review and Meta-Analysis of Observational Studies.Journal of clinical medicine · 2026Article
- Alzheimer's disease-like brain pattern biomarker: capturing risks and predicting disease onset.Molecular psychiatry · 2026Article
- White Matter Microstructural Alterations Mediate the Association between Polygenic Risk for Alzheimer's Disease and Cognitive Performance in Clinically Asymptomatic Adults.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Sex-specific early cognitive changes are linked to global and pathway-specific genetic risk for Alzheimer's disease in at-risk individuals.Biology of sex differences · 2026Article
- The impact of polygenic risk for alzheimer's disease on neurotransmitter-related grey matter atrophy in the alzheimer continuum.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Alzheimer's Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease Onset.Research square · 2025Article
- The role of serum vitamins in mediating the effect of neurodegenerative diseases on subcortical brain volume.The journal of prevention of Alzheimer's disease · 2025Article
- The independent role of fine particulate matter and genetic liability on cognition in older adults.Annals of general psychiatry · 2025Article
- Multi-modal machine learning approach for early detection of neurodegenerative diseases leveraging brain MRI and wearable sensor data.PLOS digital health · 2025Article
- Addressing overfitting bias due to sample overlap in polygenic risk scoring.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life.Nature communications · 2024Article
- APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.EMBO molecular medicine · 2024Article
- Association of polygenic risk scores with Alzheimer's disease and plasma biomarkers among Chinese older adults: A community-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Impact of Apolipoprotein E ε4 in Alzheimer's Disease: A Meta-Analysis of Voxel-Based Morphometry Studies.Journal of clinical neurology (Seoul, Korea) · 2024Article
- The impact of APOE ε4 in Alzheimer's disease: a meta-analysis of voxel-based morphometry studies.medRxiv : the preprint server for health sciences · 2024Article
- Alzheimer's disease genetic risk and changes in brain atrophy and white matter hyperintensities in cognitively unimpaired adults.Brain communications · 2024Article
- Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.Alzheimer's research & therapy · 2023Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 15 institutions in 9 countries.
Michelle K LuptonGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Electronic address: Michelle.Lupton@qimrberghofer.edu.au.
Lachlan StrikeGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.
Narelle K HansellGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.
Wei WenCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Karen A MatherCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Nicola J ArmstrongMathematics and Statistics, Murdoch University, Perth, Western Australia, Australia.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Katie L McMahonCentre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
Greig I de ZubicarayFaculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Amelia A AssarehCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Andrew SimmonsInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Petroula ProitsiInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
John F PowellInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Grant W MontgomeryGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Derrek P HibarImaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA, USA.
Eric WestmanDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Alzheimer's Disease Research Centre, Karolinska Institute, Stockholm, Sweden.
Magda TsolakiMemory and Dementia Centre, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Iwona KloszewskaDepartment of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Hilkka SoininenDepartment of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Patrizia MecocciSection of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
Bruno VelasGerontopole, CHU, UMR INSERM 1027, University of Toulouse, France.
Simon LovestoneInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Alzheimer's Disease Neuroimaging Initiative
Henry BrodatyCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
David AmesNational Ageing Research Institute, Parkville, Victoria, Australia; Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria, Australia.
Julian N TrollorCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Paul M ThompsonImaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA, USA.
Perminder S SachdevCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Margaret J WrightGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia; The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland, Australia.
King's College London · GBThe University of Queensland · AUUNSW Sydney · AUDepartment of Health and Aged Care · AUQIMR Berghofer Medical Research Institute · AUUniversity of Southern California · USAristotle University of Thessaloniki · GRInserm · FRKarolinska Institutet · SEMedical University of Lodz · PLMurdoch University · AUQueensland University of Technology · AUThe University of Melbourne · AUUniversity of Eastern Finland · FIUniversity of Perugia · IT
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MTHERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2MNorthwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MNeuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MUniversity of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI FEBO, MARCELO · 2015 to 2019
$7.3MCollaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesR01AG033193 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SESHADRI, SUDHA · 2009 to 2016
$4.4MGenetic influences on the brain: A twin imaging studyR01HD050735 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI WRIGHT, MARGARET JANE · 2007 to 2011
$2.6MAlzheimer's Society 167Medical Research Council 503480NCATS NIH HHS UL1 TR001422NHLBI NIH HHS R01 HL105756NIA NIH HHS AG081220NIA NIH HHS N01-AG-12100NIA NIH HHS P30 AG013846NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG047266NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG040060NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG032984NIA NIH HHS U24 AG021886NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD050735Wellcome TrustWellcome Trust 082604/2/07/Z
Abstract
Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16-30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults.
Indexed as
Genetic Association StudiesAdolescentAdultAgedAged, 80 and overAlzheimer DiseaseAmygdalaApolipoproteins ECase-Control StudiesCognitive DysfunctionCohort StudiesFemaleHippocampusHumansMagnetic Resonance ImagingMaleApolipoproteins EMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humanAlzheimer's diseaseAmygdalaAPOEHippocampusPolygenic risk scoreTREM2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.