Evidence map›Paper›PMID 26973104›Full record

ArticleNeurobiology of aging2016

Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring.

Jacqueline E Maye, Rebecca A Betensky, Christopher M Gidicsin, Joseph Locascio, J Alex Becker, Lesley Pepin, Jeremy Carmasin, Dorene M Rentz, Gad A Marshall, Deborah Blacker and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Parental History of Dementia Is Associated with Increased Small Vessel Cerebrovascular Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer's Study.Journal of the Royal Statistical Society. Series C, Applied statistics · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jacqueline E MayeDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Rebecca A BetenskyDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Christopher M GidicsinDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Joseph LocascioDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
J Alex BeckerDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lesley PepinDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jeremy CarmasinDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY, USA.
Dorene M RentzDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Gad A MarshallDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Deborah BlackerDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Reisa A SperlingDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Keith A JohnsonDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: kajohnson@pet.mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · USBrigham and Women's Hospital · US

Funding

Vascular factors, physical activity, and inflammation as modulators of neurodegenerative and cognitive trajectories (Project 2)P01AG036694 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI REISA A. SPERLING · 2010 to 2026
$50.2M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
Evolution of memory-related fMRI activation over the course of MCI and ADR01AG027435 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI JOHNSON, KEITH A., SPERLING, REISA A. · 2006 to 2016
$8.6M
Disentangling the contribution of tau to aging and ADR01AG046396 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSON, KEITH A. · 2014 to 2018
$4.0M
Characterizing the Evolution of Amyloid Deposition in Normal ElderlyR01AG037497 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSON, KEITH A. · 2010 to 2014
$3.2M
Neural Processes Underlying Cognitive AgingR01AG034556 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BUCKNER, RANDY L · 2009 to 2013
$2.7M
Influence of Age-related Neuropathology on Functional Brain NetworksK01AG040197 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HEDDEN, JULIUS C · 2012 to 2016
$663k
NIA NIH HHS K01 AG040197NIA NIH HHS P01 AG036694NIA NIH HHS P50 AG005134NIA NIH HHS R01 AG027435NIA NIH HHS R01 AG034556NIA NIH HHS R01 AG037497NIA NIH HHS R01 AG046396
6 · The paper itself

Abstract

Family history (FH) of dementia is a major risk factor for Alzheimer's disease, particularly when the FH is maternal and when the age of dementia onset (AO) is younger. This study tested whether brain amyloid-beta deposition, measured in vivo with (11)C-Pittsburgh compound B (PiB), was associated with parental dementia and/or younger parental AO. Detailed FH and positron emission tomography (PiB) data were acquired in 147 nondemented aging individuals (mean age 75 ± 8). No participant had both positive maternal and paternal FH. A series of analyses revealed that those with maternal, but not paternal, FH had greater levels of PiB retention in a global cortical region than those without FH. PiB retention in maternal FH was not significantly greater than paternal FH. Younger maternal dementia AO was related to greater PiB retention in offspring, whereas younger paternal dementia AO was not. Overall, results suggest that not only is amyloid-beta burden greater in individuals with maternal FH, but also that the burden is greater in association with younger maternal AO.

Indexed as

AgedAged, 80 and overAge of OnsetAmyloid beta-PeptidesAniline CompoundsBrainDementiaFemaleHumansMaleMaternal InheritancePositron-Emission TomographyThiazoles2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsThiazolesAmyloid-betaFamily historyPETPiB

Identifiers

PMID26973104
PMCPMC4792089
OpenAlexW2214833445

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.