SynthesisSeminars in arthritis and rheumatism2016
A systematic review and meta-analysis of cutaneous manifestations in late- versus early-onset systemic lupus erythematosus.
Synthesis in Seminars in arthritis and rheumatism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pulmonary manifestations in late versus early systemic lupus erythematosus: A systematic review and meta-analysis.Seminars in arthritis and rheumatism · 2018Pooled it
- Pooled it
- Age-stratified risk factors and predictive models for progression to lupus nephritis in patients with systemic lupus erythematosus: a review.Frontiers in immunology · 2025Review
- Early-onset lupus nephritis.Clinical kidney journal · 2024Review
- Relationship of regional ultraviolet index data with rash and systemic disease activity in youth with childhood-onset systemic lupus: results from the Childhood Arthritis and Rheumatology Research Alliance Registry.Pediatric rheumatology online journal · 2024Article
- Association of the Spectrum of Cutaneous Lupus Erythematosus with Disease Activity and Systemic Manifestations in Patients with Systemic Lupus Erythematosus.Mediterranean journal of rheumatology · 2024Article
- Article
- Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations.Drugs & aging · 2024Review
- The differential panorama of clinical features of lupus erythematosus patients with different onset ages: a cross-sectional multicenter study from China.Clinical rheumatology · 2023Article
- Article
- Clinical aspects of cutaneous lupus erythematosus.Frontiers in medicine · 2022Review
- Long-Term Kidney Prognosis and Pathological Characteristics of Late-Onset Lupus Nephritis.Frontiers in medicine · 2022Article
- Commentary: 'Case Report: A Rare Case of Elderly-Onset Adult Onset Still's Disease in a Patient With Systemic Lupus Erythematous'.Frontiers in immunology · 2022Article
- Cutaneous Vasculitis: Review on Diagnosis and Clinicopathologic Correlations.Clinical reviews in allergy & immunology · 2021Review
- Chinese SLE Treatment and Research Group Registry (CSTAR) XIII: prevalence and risk factors for chronic scarring alopecia in patients with systemic lupus erythematosus.Arthritis research & therapy · 2021Article
- An Elderly Gentleman with Acute Lupus Pneumonitis as the Initial Manifestation of Systemic Lupus Erythematosus.Case reports in rheumatology · 2021Article
- [Recognize rare diseases on the skin].Der Internist · 2019Review
- Validation of the Cutaneous Lupus Erythematosus Disease Area and Severity Index and pSkindex27 for use in childhood-onset systemic lupus erythematosus.Lupus science & medicine · 2018Article
- Decreased mRNA expression levels of DNA methyltransferases type 1 and 3A in systemic lupus erythematosus.Rheumatology international · 2017Article
- Ultraviolet B decreases DNA methylation level of CD4+ T cells in patients with systemic lupus erythematosus.Inflammopharmacology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesAlthough systemic lupus erythematosus (SLE) most commonly occurs in reproductive-age women, some are diagnosed after the age of 50. Recognizing that greater than one-third of SLE criteria are cutaneous, we undertook a systematic review and meta-analysis to evaluate differences in cutaneous manifestations in early- and late-onset SLE patients.
methodsWe searched the literature using PubMed, CINAHL, Web of Science, and Cochrane Library. We excluded studies that did not include ACR SLE classification criteria, early-onset controls, that defined late-onset SLE as <50 years of age, or were not written in English. Two authors rated study quality using the Newcastle Ottawa Quality Scale. We used Forest plots to compare odds ratios (95% CI) of cutaneous manifestations by age. Study heterogeneity was assessed using I(2).
resultsOverall, 35 studies, representing 11,189 early-onset and 1727 late-onset patients with SLE, met eligibility criteria. The female:male ratio was lower in the late-onset group (5:1 versus 8:1). Most cutaneous manifestations were less prevalent in the late-onset group. In particular, malar rash [OR = 0.43 (0.35, 0.52)], photosensitivity [OR = 0.72 (0.59, 0.88)], and livedo reticularis [OR = 0.33 (0.17, 0.64)] were less common in late-onset patients. In contrast, sicca symptoms were more common [OR = 2.45 (1.91, 3.14)]. The mean Newcastle Ottawa Quality Scale score was 6.3 ± 0.5 (scale: 0-9) with high inter-rater reliability for the score (0.96).
conclusionsOverall, cutaneous manifestations are less common in late-onset SLE patients, except sicca symptoms. Future studies should investigate etiologies for this phenomenon including roles of immune senescence, environment, gender, and immunogenetics.
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