Evidence map›Paper›PMID 26972745›Full record

Trial reportBehaviour research and therapy2016

Predictors of dropout in concurrent treatment of posttraumatic stress disorder and alcohol dependence: Rate of improvement matters.

Laurie J Zandberg, David Rosenfield, Elizabeth Alpert, Carmen P McLean, Edna B Foa

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Behaviour research and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  16. The development and initial validation of the Trauma-Related Alcohol Use Coping Measure (TRAC).Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laurie J ZandbergDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: zandberg@mail.med.upenn.edu.
David RosenfieldDepartment of Psychology, Southern Methodist University, Dallas, TX, USA.
Elizabeth AlpertDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Carmen P McLeanDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Edna B FoaDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USSouthern Methodist University · US

Funding

NALTREXONE AND CBT FOR PATIENTS WITH ALCOHOLISM AND PTSDR01AA012428 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI FOA, EDNA B · 2000 to 2008
$5.5M
NIAAA NIH HHS R01 AA 012428NIAAA NIH HHS R01 AA012428
6 · The paper itself

Abstract

objectiveThe present study examined predictors and moderators of dropout among 165 adults meeting DSM-IV criteria for posttraumatic stress disorder (PTSD) and alcohol dependence (AD). Participants were randomized to 24 weeks of naltrexone (NAL), NAL and prolonged exposure (PE), pill placebo, or pill placebo and PE. All participants received supportive AD counseling (the BRENDA manualized model).

methodLogistic regression using the Fournier approach was conducted to investigate baseline predictors of dropout across the entire study sample. Rates of PTSD and AD symptom improvement were included to evaluate the impact of symptom change on dropout.

resultsTrauma type and rates of PTSD and AD improvement significantly predicted dropout, accounting for 76% of the variance in dropout. Accidents and "other" trauma were associated with the highest dropout, and physical assault was associated with the lowest dropout. For participants with low baseline PTSD severity, faster PTSD improvement predicted higher dropout. For those with high baseline severity, both very fast and very slow rates of PTSD improvement were associated with higher dropout. Faster rates of drinking improvement predicted higher dropout among participants who received PE.

conclusionsThe current study highlights the influence of symptom trajectory on dropout risk. Clinicians may improve retention in PTSD-AD treatments by monitoring symptom change at regular intervals, and eliciting patient feedback on these changes.

Indexed as

AdultAlcoholismCombined Modality TherapyFemaleHumansImplosive TherapyMaleMiddle AgedNaltrexonePatient DropoutsPredictive Value of TestsSeverity of Illness IndexStress Disorders, Post-TraumaticTreatment OutcomeNaltrexoneAlcohol dependenceAttritionDropoutPost-traumatic stress disorderPredictorsProlonged exposure

Identifiers

PMID26972745
PMCPMC4828304
OpenAlexW2292706676

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.