ArticleEuropean journal of histochemistry : EJH2016
Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse.
Article in European journal of histochemistry : EJH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Expression changes in pelvic organ prolapse: a systematic review and in silico study.Scientific reports · 2017Pooled it
- A Cell-Based Therapeutic Strategy for Stress Urinary Incontinence: Functional and Molecular Evidence from Decidua-Derived Mesenchymal Stromal Cells.International journal of molecular sciences · 2026Article
- Expressions of IGF-1, pAKT, and pS6 in Uterosacral Ligaments of Patients with Pelvic Organ Prolapse.International urogynecology journal · 2025Article
- [Pathogenetically justified use in real clinical practice of vaginal estriol 0.5 mg in women of different ages].Problemy endokrinologii · 2025Article
- Role of the integrin‑β1/TGF‑β1 signaling pathway in the pathogenesis of pelvic organ prolapse: A study on vaginal wall tissue alterations and molecular dysfunction.Molecular medicine reports · 2025Article
- The Muscle Cells in Pelvic Floor Dysfunctions: Systematic Review.Muscles (Basel, Switzerland) · 2025Review
- Review
- Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells.Stem cell research & therapy · 2024Article
- Haemorrhoidal disease in pregnancy: results from a self-assessment questionnaire administered by means of a social network.BMC gastroenterology · 2024Article
- An Improved Understanding of the Pathophysiology of Pelvic Organ Prolapse: A 3D In Vitro Model under Static and Mechanical Loading Conditions.Advanced healthcare materials · 2024Article
- Early growth response 2, a novel target of pelvic organ prolapse, is highly expressed in anterior vaginal wall tissues with pelvic organ prolapse.Histochemistry and cell biology · 2024Article
- Morphological changes in the anterior vaginal wall caused by aging: a scanning electron microscopy study.International urogynecology journal · 2023Article
- Single-cell transcriptomic data reveal the increase in extracellular matrix organization and antigen presentation abilities of fibroblasts and smooth muscle cells in patients with pelvic organ prolapse.International urogynecology journal · 2023Article
- [The role of estriol in the treatment of atrophy of the mucous membrane of the lower genitourinary tract in postmenopausal women].Problemy endokrinologii · 2022Article
- Smooth Muscle Organization and Nerves in the Rat Vagina: A First Look Using Tissue Clearing and Immunolabeling.Annals of biomedical engineering · 2022Article
- Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.Scientific reports · 2021Article
- Mesenchymal stem cell transplantation for vaginal repair in an ovariectomized rhesus macaque model.Stem cell research & therapy · 2021Article
- Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse.Nature communications · 2021Article
- The Charming World of the Extracellular Matrix: A Dynamic and Protective Network of the Intestinal Wall.Frontiers in medicine · 2021Review
- Contractile Properties of Vaginal Tissue.Journal of biomechanical engineering · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the morphological and immunohistochemical alterations of tissue removed from the upper third of anterior vaginal wall in a sample group of the female population presenting homogenous risk factors associated with Pelvic Organ Prolapse (POP). The case study consisted of 14 patients with POP and there were 10 patients in the control group. Patient selection was carried on the basis of specific criteria and all of the patients involved in the study presented one or more of the recognized POP risk factors. Samples were taken from POP patients during vaginal plastic surgery following colpohysterectomy, and from control patients during closure of the posterior fornix following hysterectomy. Samples were processed for histological and immunohistochemical analyses for Collagen I and Collagen III, α-Smooth Muscle Actin (α-SMA), Platelet-Derived-Growth-Factor (PDGF), matrix metalloproteinase 3 (MMP3), Caspase3. Immunofluorescence analyses for Collagen I and III and PDGF were also carried out. In prolapsed specimens our results show a disorganization of smooth muscle cells that appeared to have been displaced by an increased collagen III deposition resulting in rearrangement of the muscularis propria architecture. These findings suggest that the increase in the expression of collagen fibers in muscularis could probably due to a phenotypic switch resulting in the dedifferentiation of smooth muscle cells into myofibroblasts. These alterations could be responsible for the compromising of the dynamic functionality of the pelvic floor.
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