ArticleInternational journal of radiation oncology, biology, physics2016
Association Between Treatment at a High-Volume Facility and Improved Survival for Radiation-Treated Men With High-Risk Prostate Cancer.
Article in International journal of radiation oncology, biology, physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic Review and Meta-analysis of the Association Between Radiation Therapy Treatment Volume and Patient Outcomes.International journal of radiation oncology, biology, physics · 2023Pooled it
- Impact of Centralizing Care for Genitourinary Malignancies to High-volume Providers: A Systematic Review.European urology oncology · 2019Pooled it
- Geographical Variations in Prostate Cancer Outcomes: A Systematic Review of International Evidence.Frontiers in oncology · 2019Pooled it
- Automated Assessment of Nondosimetric Aspects of Prostate Radiation Therapy Treatment Quality in a Large Plan Database.Advances in radiation oncology · 2026Article
- The Impact of Radiation Dose to Bowel on the Risk of Developing Gastrointestinal Toxicities When Treating Abdominopelvic Soft-Tissue Sarcomas With Preoperative Radiation Therapy.Advances in radiation oncology · 2026Article
- Rural and Urban Differences in Prostate Cancer Recurrence.JAMA network open · 2025Article
- Patterns of care in pancreatic cancer radiotherapy: impact of facility volume on outcomes.Frontiers in oncology · 2025Article
- Postprostatectomy Radiotherapy Timing and Long-Term Health-Related Quality of Life.JAMA network open · 2024Article
- Prostate cancer treatment in Portugal: a nationwide analysis.Scientific reports · 2023Article
- Radiation Oncology Health Disparities in Pakistan.JCO global oncology · 2023Article
- Radiation Facility Volume and Survival for Men With Very High-Risk Prostate Cancer Treated with Radiation and Androgen Deprivation Therapy.JAMA network open · 2023Article
- Hospital facility characteristics and socioeconomic factors on outcomes and treatment in patients with multiple myeloma: National Cancer Database analysis.Annals of hematology · 2023Article
- The centralization of bladder cancer care and its implications for patient travel distance.Urologic oncology · 2021Article
- Strengths and Limitations of Registries in Surgical Oncology Research.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Review
- Analysis of Radiation Facility Volume and Survival in Men With Lymph Node-Positive Prostate Cancer Treated With Radiation and Androgen Deprivation Therapy.JAMA network open · 2020Article
- Urologist practice structure and quality of prostate cancer care.Urology practice · 2020Article
- Treatment Facility Volume and Survival in Patients with Advanced Prostate Cancer.European urology oncology · 2020Article
- Article
- Racial/ethnic differences in survival for patients with gliosarcoma: an analysis of the National cancer database.Journal of neuro-oncology · 2019Article
- Regional trends in average years of potential life lost (AYPLL) secondary to prostate cancer deaths among Caucasians and African Americans treated by surgery or radiation.International urology and nephrology · 2019Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough the association between higher hospital volume and improved outcomes has been well-documented in surgery, there is little data about whether this effect exists for radiation-treated patients. We investigated whether treatment at a radiation facility that treats a high volume of prostate cancer patients is associated with improved survival for men with high-risk prostate cancer. METHODS AND MATERIALS: We used the National Cancer Database (NCDB) to identity patients diagnosed with prostate cancer from 2004 to 2006. The radiation case volume (RCV) of each hospital was based on its number of radiation-treated prostate cancer patients. We used propensity-score based analysis to compare the overall survival (OS) of high-risk prostate cancer patients in high versus low RCV hospitals. Primary endpoint is overall survival. Covariates adjusted for were tumor characteristics, sociodemographic factors, radiation type, and use of androgen deprivation therapy (ADT).
resultsA total of 19,565 radiation-treated high-risk patients were identified. Median follow-up was 81.0 months (range: 1-108 months). When RCV was coded as a continuous variable, each increment of 100 radiation-managed patients was associated with improved OS (adjusted hazard ratio [AHR]: 0.97; 95% confidence interval [CI]: 0.95-0.98; P<.0001) after adjusting for known confounders. For illustrative purposes, when RCV was dichotomized at the 80th percentile (43 patients/year), high RCV was associated with improved OS (7-year overall survival 76% vs 74%, log-rank test P=.0005; AHR: 0.91, 95% CI: 0.86-0.96, P=.0005). This association remained significant when RCV was dichotomized at 75th (37 patients/year), 90th (60 patients/year), and 95th (84 patients/year) percentiles but not the 50th (19 patients/year).
conclusionsOur results suggest that treatment at centers with higher prostate cancer radiation case volume is associated with improved OS for radiation-treated men with high-risk prostate cancer.
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