ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2016
Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Growth of Oxygen Environment of the Newborn Vocal Fold Maculae Flavae as a Stem Cell Niche.Laryngoscope investigative otolaryngology · 2026Article
- AHCC inhibited hepatic stellate cells activation by regulation of cytoglobin induction via TLR2-SAPK/JNK pathway and collagen production via TLR4-NF-κβ pathway.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Hyperbaric oxygen therapy in the ATLS/ACLS resuscitative management of acutely ill or severely injured patients with severe anemia: a review.Frontiers in medicine · 2024Review
- Insights into the function of cytoglobin.Biochemical Society transactions · 2023Review
- Role of ferroptosis in colorectal cancer.World journal of gastrointestinal oncology · 2023Review
- Twelve protections evolved for the brain, and their roles in extending its functional life.Frontiers in neuroanatomy · 2023Review
- Heme-Protein Interactions and Functional Relevant Heme Deformations: The Cytochrome c Case.Molecules (Basel, Switzerland) · 2022Review
- Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations.Antioxidants (Basel, Switzerland) · 2022Article
- Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response.Antioxidants (Basel, Switzerland) · 2022Article
- Isolated Diaphorase From Bovine Erythrocyte Cannot Reduce Oxidized Cytoglobin (Metcygb).Reports of biochemistry & molecular biology · 2022Article
- Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease.International journal of molecular sciences · 2021Review
- Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells.Journal of cellular and molecular medicine · 2021Article
- Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin.Molecular medicine reports · 2021Article
- Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.Nature communications · 2020Article
- Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin.Antioxidants & redox signaling · 2020Review
- Fibrosis reversal after hepatitis C virus elimination.Current opinion in gastroenterology · 2019Review
- Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts.Biological research · 2019Article
- The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor.Redox biology · 2018Article
- Defining the reducing system of the NO dioxygenase cytoglobin in vascular smooth muscle cells and its critical role in regulating cellular NO decay.The Journal of biological chemistryArticle
- Hepatic stellate cells - from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytoglobin (CYGB), a new member of the globin family, was discovered in 2001 as a protein associated with stellate cell activation (stellate cell activation-associated protein [STAP]). Knowledge of CYGB, including its crystal, gene, and protein structures as well as its physiological and pathological importance, has increased progressively. We investigated the roles of oxygen (O2)-binding CYGB as STAP in hepatic stellate cells (HSCs) to understand the part played by this protein in their pathophysiological activities. Studies involving CYGB-gene-deleted mice have led us to suppose that CYGB functions as a regulator of O2 homeostasis; when O2 homeostasis is disrupted, HSCs are activated and play a key role(s) in hepatic fibrogenesis. In this review, we discuss the rationale for this hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.