ArticleSchizophrenia research2016
Altered expression of developmental regulators of parvalbumin and somatostatin neurons in the prefrontal cortex in schizophrenia.
Article in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- The role ofEpigenetics · 2026Review
- Early-life medial pulvinar disruption drives schizophrenia-relevant prefrontal inhibitory and cognitive deficits in primates.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- epDevAtlas: mapping GABAergic cells and microglia in the early postnatal mouse brain.Nature communications · 2025Article
- The role of dorsomedial striatum and parvalbumin interneurons in schizophrenia-related cognitive deficits: insights from disrupted strategic decision-making in Akt1 heterozygous mice.Translational psychiatry · 2025Article
- Exploration on the potential efficacy and mechanism of methyl salicylate glycosides in the treatment of schizophrenia based on bioinformatics, molecular docking and dynamics simulation.Schizophrenia (Heidelberg, Germany) · 2024Article
- epDevAtlas: Mapping GABAergic cells and microglia in postnatal mouse brains.bioRxiv : the preprint server for biology · 2023Article
- Evolutionarily recent retrotransposons contribute to schizophrenia.Translational psychiatry · 2023Article
- Evolutionarily recent retrotransposons contribute to schizophrenia.Research square · 2023Article
- Article
- Upper cortical layer-driven network impairment in schizophrenia.Science advances · 2022Article
- Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET).European journal of nuclear medicine and molecular imaging · 2022Article
- Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia.Molecular brain · 2021Article
- Cocaine memory reactivation induces functional adaptations within parvalbumin interneurons in the rat medial prefrontal cortex.Addiction biology · 2021Article
- Stress impacts corticoamygdalar connectivity in an age-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner.Molecular psychiatry · 2020Article
- Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons.Human molecular genetics · 2020Article
- Enriched Environment Reverts Somatostatin Interneuron Loss in MK-801 Model of Schizophrenia.Molecular neurobiology · 2020Article
- Expression of Transcripts Selective for GABA Neuron Subpopulations across the Cortical Visuospatial Working Memory Network in the Healthy State and Schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Dysfunction of prefrontal cortex (PFC) inhibitory neurons that express the calcium-binding protein parvalbumin or the neuropeptide somatostatin in schizophrenia may be related to disturbances in the migration, phenotypic specification, and/or maturation of these neurons. These pre- and postnatal developmental stages are regulated in a cell type-specific manner by various transcription factors and co-activators, fibroblast growth factor receptors (FgfR), and other molecular markers. Consequently, we used quantitative PCR to quantify mRNA levels for these developmental regulators in the PFC of 62 schizophrenia subjects in whom parvalbumin and somatostatin neuron disturbances were previously reported, and in antipsychotic-exposed monkeys. Relative to unaffected comparison subjects, subjects with schizophrenia exhibited elevated mRNA levels for 1) the transcription factor MafB, which is expressed by parvalbumin and somatostatin neurons as they migrate from the medial ganglionic eminence to the cortex, 2) the transcriptional coactivator PGC-1α, which is expressed postnatally by parvalbumin neurons to maintain parvalbumin levels and inhibitory function, and 3) FgfR1, which is required for the migration and phenotypic specification of parvalbumin and somatostatin neurons. Elevations in these markers were most prominent in younger schizophrenia subjects and were not present in antipsychotic-exposed monkeys. Finally, expression levels of other important developmental regulators (i.e. Dlx1, Dlx5, Dlx6, SATB1, Sip1/Zeb2, ST8SIA4, cMaf, Nkx6.2, and Arx) were not altered in schizophrenia. The over-expression of a subset of molecular markers with distinct roles in the pre- and postnatal development of parvalbumin and somatostatin neurons might reflect compensatory mechanisms to sustain the development of these neurons in the face of other insults.
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