Evidence map›Paper›PMID 26972467›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2016

Biodegradable, Tethered Lipid Bilayer-Microsphere Systems with Membrane-Integrated α-Helical Peptide Anchors.

Eric S Fried, Joshua Luchan, M Lane Gilchrist

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eric S FriedDepartment of Chemical Engineering and ‡Department of Biomedical Engineering, The City College of the City University of New York , 140th Street and Convent Avenue, New York, New York 10031, United States.
Joshua LuchanDepartment of Chemical Engineering and ‡Department of Biomedical Engineering, The City College of the City University of New York , 140th Street and Convent Avenue, New York, New York 10031, United States.
M Lane GilchristDepartment of Chemical Engineering and ‡Department of Biomedical Engineering, The City College of the City University of New York , 140th Street and Convent Avenue, New York, New York 10031, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Training and Career Development CoreU54CA132378 · NCI · CITY COLLEGE OF NEW YORK · PI Tim Alan Ahles, ADRIANA ESPINOSA · 2008 to 2026
$28.9M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Daniel Alan Heller · 2008 to 2026
$28.1M
VOLTAGE GATING OF ION CHANNELS--SIMULATIONS AND AB INITIO CALCULATIONSS06GM008168 · NIGMS · CITY COLLEGE OF NEW YORK · PI VENKATESH, TADMIRI RANGACHAR · 1989 to 2010
$17.6M
NCI NIH HHS P30 CA008748NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788NCI NIH HHS U54CA137788/U54CA132378NIGMS NIH HHS S06 GM008168NIGMS NIH HHS S06GM008168-2
6 · The paper itself

Abstract

Supported lipid bilayers (SLBs) are ideally suited for the study of biomembrane-biomembrane interactions and for the biomimicry of cell-to-cell communication, allowing for surface ligand displays that contain laterally mobile elements. However, the SLB paradigm does not include three-dimensionality and biocompatibility. As a way to bypass these limitations, we have developed a biodegradable form of microsphere SLBs, also known as proteolipobeads (PLBs), using PLGA microspheres. Microspheres were synthesized using solvent evaporation and size selected with fluorescence activated cell sorting (FACS). Biomembranes were covalently tethered upon fusion to microsphere supports via short-chain PEG spacers connecting membrane-integrated α-helical peptides and the microsphere surface, affecting membrane diffusivity and mobility as indicated by confocal FRAP analysis. Membrane heterogeneities, which are attributed to PLGA hydrophobicity and rough surface topography, are curtailed by the addition of PEG tethers. This method allows for the presentation of tethered, laterally mobile biomembranes in three dimensions with functionally embedded attachment peptides for mobile ligand displays.

Indexed as

MicrospheresBiodegradable PlasticsLactic AcidLipid BilayersMembrane ProteinsParticle SizePeptidesPhosphatidylcholinesPolyethylene GlycolsPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerProtein Structure, Secondary1,2-oleoylphosphatidylcholineBiodegradable PlasticsLactic AcidLipid BilayersMembrane ProteinsPeptidesPhosphatidylcholinesPolyethylene GlycolsPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymer

Identifiers

PMID26972467
PMCPMC4911039

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.