Trial reportJournal of veterinary internal medicine2016
Evaluation of Clinical Metrology Instrument in Dogs with Osteoarthritis.
Trial report in Journal of veterinary internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Prospective, randomized, placebo-controlled, multicenter, double-blind, parallel-group, registration field trial evaluating izenivetmab, a caninized anti-nerve growth factor monoclonal antibody, administered quarterly to dogs with naturally occurring osteoarthritis.Veterinary and animal science · 2026Article
- Effects of Extracorporeal Shockwave Therapy on Pain and Mobility in Client-Owned Dogs with Refractory Elbow and Stifle Osteoarthritis: A Randomized Double-Blinded Trial.Animals : an open access journal from MDPI · 2026Article
- Automatic gait analysis in canines using computer vision.Frontiers in veterinary science · 2026Review
- Factors influencing, and associated with, physical activity patterns in dogs with osteoarthritis-associated pain.Frontiers in veterinary science · 2025Article
- Efficacy of a joint supplement containing eggshell membrane among other ingredients to improve the mobility of dogs with osteoarthritis: a multicenter double-blind randomized placebo-controlled study.Frontiers in veterinary science · 2025Article
- Outcome assessment in veterinary pain studies: a pain in animals workshop (PAW) perspective.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- A proposed framework for practical multimodal management of osteoarthritis in growing dogs.Frontiers in veterinary science · 2025Review
- Evaluation of the effect of cannabidiol administration with and without nonsteroidal anti-inflammatory drugs in dogs with mobility disorders: a prospective, double-blind, crossover, placebo-controlled study.Frontiers in veterinary science · 2024Article
- Translation and linguistic validation into Spanish of the Owner-Reported Outcome Measure "Liverpool Osteoarthritis in Dogs".Frontiers in veterinary science · 2024Article
- Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review.BMC veterinary research · 2023Review
- Translation to Spanish and linguistic validation of the Canine Brief Pain Inventory.Frontiers in veterinary science · 2023Article
- Article
- GenPup-M: A novel validated owner-reported clinical metrology instrument for detecting early mobility changes in dogs.PloS one · 2023Article
- Evaluation of Four Clinical Metrology Instruments for the Assessment of Osteoarthritis in Dogs.Animals : an open access journal from MDPI · 2022Article
- Impact of supplemented undenatured type II collagen on pain and mobility in healthy Labrador Retrievers during an exercise regimen.Translational animal science · 2022Article
- Initial exploration of the discriminatory ability of the PetPace collar to detect differences in activity and physiological variables between healthy and osteoarthritic dogs.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- The beneficial role of companion animals in translational pain research.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- A report on the use of a single intra-articular administration of autologous platelet therapy in a naturally occurring canine osteoarthritis model - a preliminary study.BMC musculoskeletal disorders · 2020Article
- Intra-articular Injections With Either Triamcinolone Hexacetonide, Stanozolol, Hylan G-F 20, or a Platelet Concentrate Improve Clinical Signs in Police Working Dogs With Bilateral Hip Osteoarthritis.Frontiers in veterinary science · 2020Article
- Evaluation of the Effects of Undenatured Type II Collagen (UC-II) as Compared to Robenacoxib on the Mobility Impairment Induced by Osteoarthritis in Dogs.Veterinary sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIn veterinary clinical pain studies, there is a paucity of data on test-retest variability in Clinical Metrology Instruments (CMIs), and it is unknown whether CMIs should be administered using independent (respondents not permitted to see previous answers) or dependent (respondents shown previous answers) interviewing.
objectivesTo compare baseline variability in CMIs designed to assess pain in dogs with osteoarthritis, and compare CMI scores using independent (InD) and dependent interviewing (DI) for the Canine Brief Pain Inventory (CBPI) and the Client-Specific Outcome Measures (CSOM). ANIMALS: Fifty-one client-owned dogs with radiographic evidence of osteoarthritis and associated pain.
methodsClinical Metrology Instruments data were collected during 2 randomized, double-masked, placebo-controlled, proof of principle pilot studies with parallel treatment groups. Enrolled dogs received either placebo or antinerve growth factor antibody (NV-01).
resultsAgreement between baseline CMI scores was good (CBPI Pain P = .29, CBPI Interference P = .32, CSOM P = .036, LOAD P = .67, HCPI P = .27), being best for the LOAD (ICC = 0.89). CMI responses collected during independent and dependent interviewing were not statistically different (CBPI Pain P = .33, CBPI Interference P = .28, CSOM P = .42) and showed good agreement. Additionally, dependent interviewing resulted in increased treatment effect sizes. CONCLUSIONS AND CLINICAL IMPORTANCE: There is little difference between independent and dependent interviewing, however, dependent interviewing resulted in increased treatment effect sizes. By using dependent interviewing, investigators could increase clinical trial power through minimal change to study design. Further research is warranted to investigate the use of dependent interviewing.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.