Evidence map›Paper›PMID 26971871›Full record

ArticleCell chemical biology2016

Uncovering the Serine Hydrolytic Landscape of Mycobacterium tuberculosis.

Helena I Boshoff

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Discovery ofFrontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Helena I BoshoffTuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: hboshoff@niaid.nih.gov.

Funding

Development Of New Chemotherapeutics For TuberculosisZIAAI000693 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARRY, CLIFTON · 2009 to 2025
$20.1M
Exploring the metabolism of non-replicating and drug-resistant TBZIAAI000783 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARRY, CLIFTON · 2009 to 2017
$8.2M
Intramural NIH HHS ZIA AI000783
6 · The paper itself

Abstract

In this issue of Cell Chemical Biology, Ortega et al. (2016) present a study utilizing a click-chemistry-enabled fluorophosphonate for activity-based identification of serine hydrolases, pinpointing a range of proteins including previously annotated hypotheticals. The application of this technology on both actively replicating and non-replicating Mycobacterium tuberculosis gives us a glimpse of its serine hydrolytic landscape during different stages of metabolic activity.

Indexed as

SerineAntitubercular AgentsBacterial ProteinsHydrolasesHydrolysisMycobacteriumMycobacterium smegmatisMycobacterium tuberculosisNontuberculous MycobacteriaSerine EndopeptidasesSerine O-AcetyltransferaseSerine ProteasesSerine Proteinase InhibitorsTuberculosisAntitubercular AgentsBacterial ProteinsHydrolasesSerineSerine EndopeptidasesSerine O-AcetyltransferaseSerine ProteasesSerine Proteinase Inhibitors

Identifiers

PMID26971871
PMCPMC6350241

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.