Trial reportJournal of veterinary internal medicine2016
Effect of Parenteral Antioxidant Supplementation During the Dry Period on Postpartum Glucose Tolerance in Dairy Cows.
Trial report in Journal of veterinary internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of antioxidant and calcium slow-release boluses administration on metabolic status, production, and reproductive performance of dairy cows during the summer season.Tropical animal health and production · 2026Article
- Effects of AD3EC and Ca-P-Mg Supplementation on Oxidative Stress in Postpartum Dairy Cows.Veterinary medicine international · 2026Article
- Preparturient Oral Selenitetriglycerides Supplementation Elevates Erythrocyte Glutathione Peroxidase Activity and Modulates HepaticInternational journal of molecular sciences · 2025Article
- Selenium-Biofortified Alfalfa Hay Supplemented to Jersey and Holstein Dairy Heifers During the Peripartum Period: Effects on Dams and Their Offspring.Animals : an open access journal from MDPI · 2025Article
- Impact of Parenteral Maternal Supplementation with Trace Minerals and Vitamins on Neonatal Calf Antioxidant System and Growth in a Dairy Herd.Animals : an open access journal from MDPI · 2024Article
- Effect of sustained-release antioxidant bolus on body condition score, blood parameters, uterine health, and some reproductive parameters in transition dairy cows under heat stress condition.Tropical animal health and production · 2023Article
- Effect of sustained release bolus oral administration on body condition change, blood parameters, and uterine health in primiparous cows under heat stress.Tropical animal health and production · 2023Article
- Effect of Supplementing Vitamin E, Selenium, Copper, Zinc, and Manganese during the Transition Period on Dairy Cow Reproductive Performance and Immune Function.Veterinary sciences · 2023Article
- The Antioxidant Properties of Selenium and Vitamin E; Their Role in Periparturient Dairy Cattle Health Regulation.Antioxidants (Basel, Switzerland) · 2021Review
- Effects of supplemental Bacillus subtilis, injectable vitamin E plus selenium, or both on health parameters during the transition period in dairy cows in a tropical environment.Tropical animal health and production · 2021Article
- Effect of preshipment preconditioning and injectable antioxidant trace elements (Cu, Mn, Se, Zn) and vitamins (A, E) on plasma metabolite and hormone concentrations and growth in weaned beef cattle.Translational animal science · 2021Article
- Effects of Parenteral Supplementation with Minerals and Vitamins on Oxidative Stress and Humoral Immune Response of Weaning Calves.Animals : an open access journal from MDPI · 2020Article
- Redox Biology in Transition Periods of Dairy Cattle: Role in the Health of Periparturient and Neonatal Animals.Antioxidants (Basel, Switzerland) · 2019Review
- Effects of auditory and visual stimuli on glucose metabolism in Holstein dairy cattle.Acta veterinaria Scandinavica · 2019Article
- A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species-A Critical Review.International journal of molecular sciences · 2017Review
- The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats.Biological trace element research · 2017Article
- Selenium in Cattle: A Review.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExacerbated postparturient insulin resistance (IR) has been associated with several pathologic conditions in dairy cattle. Oxidative stress (OS) plays a causative role in IR in humans, and an association, but not direct relationship, between OS and IR recently has been reported in transition dairy cattle. HYPOTHESIS: Supplementation with antioxidants shortly before calving improves glucose tolerance after parturition in dairy cattle. ANIMALS: Ten late-pregnant Holstein cows entering their 2nd to 5th lactation.
methodsRandomized placebo-controlled trial: 15 ± 2 days before expected calving, the treatment group received an injection of DL-alpha-tocopheryl acetate at a dosage of 6 mg/kg body weight (BW) and 0.06 mg/kg BW of sodium selenite, and the control group was injected with isotonic saline. During the first week after calving, both groups underwent glucose tolerance testing (0.25 g glucose/kg BW). Commercial assays were used to quantify the concentrations of glucose, insulin, nonesterified fatty acids (NEFA), beta-hydroxybutyrate, and markers of redox status in blood. Data were analyzed using the Mann-Whitney U-test (α = 0.05).
resultsSupplemented cows showed a lower risk for OS, as reflected by a lower OS index (P = .036), different areas under the curve for the concentrations of glucose (P < .01), insulin (P = .043), and NEFA (P = .041), more rapid elimination rates (P = .080, <.01 and .047 respectively), and shorter half-lives (P = .040, <.01 and .032) of these metabolites. CONCLUSIONS AND CLINICAL IMPORTANCE: Supplementation with antioxidants before calving resulted in greater insulin sensitivity after calving, thereby suggesting the role of OS in the development of IR in cattle and the potential benefits of antioxidant supplementation in minimizing the consequences of negative energy balance.
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